患有中度或重度持续性哮喘的青少年和成人的三重吸入器治疗。

IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Jaapa-Journal of the American Academy of Physician Assistants Pub Date : 2025-01-01 Epub Date: 2024-12-19 DOI:10.1097/01.JAA.0000000000000153
Mark L'Eplattenier, Gina Pontrelli, Carina Loscalzo
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引用次数: 0

摘要

摘要:专家指南、荟萃分析和多项随机对照试验表明,长效吸入抗毒蕈碱药物(LAMAs)作为一种辅助药物治疗控制不佳的中重度持续性哮喘患者的有效性。LAMAs在阻断乙酰胆碱与毒蕈碱受体结合和减少支气管收缩和粘液产生方面发挥重要作用。通过将这种药物添加到其他联合吸入器中,患者可以使用三重吸入器来改善FEV1值并减少恶化。
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Triple inhaler therapy in adolescents and adults with moderate or severe persistent asthma.

Abstract: Expert guidelines, meta-analyses, and multiple randomized controlled trials have demonstrated the effectiveness of long-acting inhaled antimuscarinic agents (LAMAs) as an additive medication for patients with poorly controlled moderate or severe persistent asthma. LAMAs play an essential role in blocking acetylcholine binding to muscarinic receptors and reducing bronchoconstriction and mucus production. By adding this medication to other combination inhalers, patients can use a triple inhaler to improve FEV1 values and reduce exacerbations.

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来源期刊
CiteScore
1.20
自引率
9.10%
发文量
310
期刊介绍: ​​​JAAPA is the peer-reviewed clinical journal of the American Academy of Physician Assistants (AAPA). Published for more than 25 years, its mission is to support the ongoing education and advancement of physician assistants (PAs) by publishing current information and research on clinical, health policy, and professional issues. Published monthly, JAAPA''s award-winning editorial includes: -Clinical review articles (with AAPA-approved Category I CME in each issue)- Case reports- Clinical departments- Original health services research- Articles on issues of professional interest to PAs
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