{"title":"在睡眠中磷酸酶和激酶之间的拉锯战","authors":"Niels Niethard, Jan Born","doi":"10.1038/s41422-024-01065-5","DOIUrl":null,"url":null,"abstract":"<p><b>In a recent work published in</b> <b><i>Nature</i></b><b>, Wang et al. reveal how protein kinase A and calcineurin dynamically regulate the daily duration of sleep and wake periods at excitatory post-synapses in the brain. This study uncovers key molecular mechanisms offering new insights into the enzymatic control of sleep homeostasis.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"10 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tug of war between phosphatase and kinase during sleep\",\"authors\":\"Niels Niethard, Jan Born\",\"doi\":\"10.1038/s41422-024-01065-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>In a recent work published in</b> <b><i>Nature</i></b><b>, Wang et al. reveal how protein kinase A and calcineurin dynamically regulate the daily duration of sleep and wake periods at excitatory post-synapses in the brain. This study uncovers key molecular mechanisms offering new insights into the enzymatic control of sleep homeostasis.</b></p>\",\"PeriodicalId\":9926,\"journal\":{\"name\":\"Cell Research\",\"volume\":\"10 1\",\"pages\":\"\"},\"PeriodicalIF\":28.1000,\"publicationDate\":\"2024-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41422-024-01065-5\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-024-01065-5","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Tug of war between phosphatase and kinase during sleep
In a recent work published inNature, Wang et al. reveal how protein kinase A and calcineurin dynamically regulate the daily duration of sleep and wake periods at excitatory post-synapses in the brain. This study uncovers key molecular mechanisms offering new insights into the enzymatic control of sleep homeostasis.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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