三例皮革制品中的 2-(硫氰基甲硫基)苯并噻唑过敏性接触性皮炎病例。

IF 4.8 1区 医学 Q2 ALLERGY Contact Dermatitis Pub Date : 2024-12-20 DOI:10.1111/cod.14737
Quentin Samaran, Olivier Dereure, Nadia Raison-Peyron
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引用次数: 0

摘要

背景:2-(硫氰基甲基硫)苯并噻唑(TCMTB)是20世纪90年代以来广泛应用于皮革工业的杀菌剂。然而,这种化学物质引发的过敏性接触性皮炎的报道很少。目的:调查3例可能与TCMTB有关的皮革制品接触后皮炎病例。方法:3例女性患者,年龄33-53岁,疑似与皮革制品相关的过敏性接触性皮炎。2例患者表现为足部皮炎,1例患者表现为背部和大腿皮炎。所有患者使用欧洲基线系列、鞋类系列、TMCTB (0.1% pet)和个人皮革制品的刮擦物进行补丁测试。结果:所有患者对个人产品刮擦(+ ~ ++)和TCMTB(++ ~ ++)均有反应。此外,一名患者对巯基混合物和巯基苯并噻唑(均为++)敏感,而另一名患者对铬(++)、钴(+)、4-叔丁基酚醛树脂(+)和树脂(++)敏感。建议所有患者避免使用TCMTB,并谨慎使用皮革、合成革和清漆木材。结论:如果怀疑与皮革接触有关的接触性皮炎,应包括用0.1%的TCMTB pet进行斑贴试验,因为这可能是唯一的阳性发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Three Cases of Allergic Contact Dermatitis to 2-(Thiocyanomethylthio)benzothiazole in Leather Items

Background

2-(Thiocyanomethylthio)benzothiazole (TCMTB) is a fungicide product widely used in the leather industry, particularly since the 1990s. However, reports of allergic contact dermatitis triggered by this chemical are scarce.

Objectives

To investigate three cases of dermatitis following contact with leather products, possibly related to TCMTB.

Methods

Three female patients, aged 33–53, were referred with suspected allergic contact dermatitis related to leather products. Two patients presented with dermatitis on the feet, while one patient had dermatitis on the back and thighs. All patients were patch-tested with the European baseline series, a shoe series, TMCTB (0.1% pet), and scrapings from their personal leather products.

Results

All patients showed reactions to the scrapings from their personal products (+ to ++) and to TCMTB (++ to +++). Additionally, one patient was sensitised to mercapto mix and mercaptobenzothiazole (both ++), while another reacted to chromium (++), cobalt (+), 4-tert-butylphenol-formaldehyde resin (+) and colophonium (++). All patients were advised to avoid TCMTB and to be cautious with leather, synthetic leather, and varnished wood.

Conclusions

If contact dermatitis related to leather exposure is suspected, patch testing with TCMTB 0.1% pet should be included, as it might be the only positive finding.

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来源期刊
Contact Dermatitis
Contact Dermatitis 医学-过敏
CiteScore
4.60
自引率
30.90%
发文量
227
审稿时长
4-8 weeks
期刊介绍: Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".
期刊最新文献
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