S.A.J.E.A. Lagerweij , J.C. van Zijl , M. Smit , H. Eggink , D.L.M. Oterdoom , J.M.C. van Dijk , M.E. van Egmond , J.W. Elting , M.A.J. Tijssen
{"title":"共同收缩诱发任务中的肌间连贯性是肌张力障碍和 GPi-DBS 疗效的生物标记。","authors":"S.A.J.E.A. Lagerweij , J.C. van Zijl , M. Smit , H. Eggink , D.L.M. Oterdoom , J.M.C. van Dijk , M.E. van Egmond , J.W. Elting , M.A.J. Tijssen","doi":"10.1016/j.clinph.2024.12.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Clinical rating scales often fail to capture the full spectrum of dystonic symptoms. Deep brain stimulation of the globus pallidus interna (GPi-DBS) effectively treats dystonia, but response variability necessitates a reliable biomarker. Intermuscular coherence (4–12 Hz) has been linked to abnormal activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop and may serve as an objective measure of dystonia and GPi-DBS effectiveness.</div></div><div><h3>Methods</h3><div>A retrospective cohort study included 12 dystonia patients undergoing GPi-DBS implantation. Clinical rating scales and a neurophysiological assessment were performed before and one year post-DBS. Coherence in the 4–12 Hz range was analyzed from electromyography (EMG) of antagonistic arm muscles. Comparisons were made between patients with and without arm dystonia, t-tests evaluated the differences between pre- and post-DBS, and correlations between coherence and clinical scales were performed.</div></div><div><h3>Results</h3><div>Seven patients with arm dystonia appeared to have higher pre-operative intermuscular coherence compared to those without. Coherence was significantly decreased after GPi-DBS in the arm dystonia group. No strong correlations were found between coherence and clinical rating scales.</div></div><div><h3>Conclusion</h3><div>Intermuscular coherence is present in dystonic muscles and decreases following GPi-DBS. Correlations with motor scores were inconclusive due to patient heterogeneity and ill-fitting clinical scales.</div></div><div><h3>Significance</h3><div>Intermuscular coherence has potential to aid GPi-DBS patient selection and optimization but larger studies are needed to validate its use.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 70-79"},"PeriodicalIF":3.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intermuscular coherence during co-contraction eliciting tasks as a biomarker for dystonia and GPi-DBS efficacy\",\"authors\":\"S.A.J.E.A. Lagerweij , J.C. van Zijl , M. Smit , H. Eggink , D.L.M. Oterdoom , J.M.C. van Dijk , M.E. van Egmond , J.W. Elting , M.A.J. Tijssen\",\"doi\":\"10.1016/j.clinph.2024.12.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>Clinical rating scales often fail to capture the full spectrum of dystonic symptoms. Deep brain stimulation of the globus pallidus interna (GPi-DBS) effectively treats dystonia, but response variability necessitates a reliable biomarker. Intermuscular coherence (4–12 Hz) has been linked to abnormal activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop and may serve as an objective measure of dystonia and GPi-DBS effectiveness.</div></div><div><h3>Methods</h3><div>A retrospective cohort study included 12 dystonia patients undergoing GPi-DBS implantation. Clinical rating scales and a neurophysiological assessment were performed before and one year post-DBS. Coherence in the 4–12 Hz range was analyzed from electromyography (EMG) of antagonistic arm muscles. Comparisons were made between patients with and without arm dystonia, t-tests evaluated the differences between pre- and post-DBS, and correlations between coherence and clinical scales were performed.</div></div><div><h3>Results</h3><div>Seven patients with arm dystonia appeared to have higher pre-operative intermuscular coherence compared to those without. Coherence was significantly decreased after GPi-DBS in the arm dystonia group. No strong correlations were found between coherence and clinical rating scales.</div></div><div><h3>Conclusion</h3><div>Intermuscular coherence is present in dystonic muscles and decreases following GPi-DBS. Correlations with motor scores were inconclusive due to patient heterogeneity and ill-fitting clinical scales.</div></div><div><h3>Significance</h3><div>Intermuscular coherence has potential to aid GPi-DBS patient selection and optimization but larger studies are needed to validate its use.</div></div>\",\"PeriodicalId\":10671,\"journal\":{\"name\":\"Clinical Neurophysiology\",\"volume\":\"170 \",\"pages\":\"Pages 70-79\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neurophysiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1388245724003729\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1388245724003729","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Intermuscular coherence during co-contraction eliciting tasks as a biomarker for dystonia and GPi-DBS efficacy
Objective
Clinical rating scales often fail to capture the full spectrum of dystonic symptoms. Deep brain stimulation of the globus pallidus interna (GPi-DBS) effectively treats dystonia, but response variability necessitates a reliable biomarker. Intermuscular coherence (4–12 Hz) has been linked to abnormal activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop and may serve as an objective measure of dystonia and GPi-DBS effectiveness.
Methods
A retrospective cohort study included 12 dystonia patients undergoing GPi-DBS implantation. Clinical rating scales and a neurophysiological assessment were performed before and one year post-DBS. Coherence in the 4–12 Hz range was analyzed from electromyography (EMG) of antagonistic arm muscles. Comparisons were made between patients with and without arm dystonia, t-tests evaluated the differences between pre- and post-DBS, and correlations between coherence and clinical scales were performed.
Results
Seven patients with arm dystonia appeared to have higher pre-operative intermuscular coherence compared to those without. Coherence was significantly decreased after GPi-DBS in the arm dystonia group. No strong correlations were found between coherence and clinical rating scales.
Conclusion
Intermuscular coherence is present in dystonic muscles and decreases following GPi-DBS. Correlations with motor scores were inconclusive due to patient heterogeneity and ill-fitting clinical scales.
Significance
Intermuscular coherence has potential to aid GPi-DBS patient selection and optimization but larger studies are needed to validate its use.
期刊介绍：
As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology.
Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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