转录偶联修复-作用机制，调节，和相关的人类疾病。

IF 3 4区生物学 Q1 Biochemistry, Genetics and Molecular Biology FEBS Letters Pub Date : 2024-12-20 DOI:10.1002/1873-3468.15073

Yuka Nakazawa, Yasuyoshi Oka, Tomoko Matsunaga, Tomoo Ogi

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引用次数: 0

摘要

转录偶联修复（TCR）途径解决转录阻断DNA损伤以维持细胞功能并防止转录阻滞。停滞的RNA聚合酶II （RNAPII）触发修复机制，包括RNAPII泛素化，招募uvsa和TFIIH。tcr相关基因的缺陷导致疾病，如柯凯因综合征、紫外线敏感综合征、色素性干皮病和最近定义的AMeDS。TCR保护转录，将其失败与神经变性和疾病表型联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcription-coupled repair – mechanisms of action, regulation, and associated human disorders

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

7.00

自引率

2.90%

发文量

303

审稿时长

1.0 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.