实体器官移植受者接种Covid-19 mRNA后排斥事件发生的时间

IF 4.5 3区医学 Q2 IMMUNOLOGY Vaccine Pub Date : 2025-01-25 DOI:10.1016/j.vaccine.2024.126617

Quentin Perrier , Johan Noble , Agnès Bonadona , Caroline Augier , Thomas Jouve , Aude Boignard , Loïc Falque , Salomé Gallet , Pierrick Bedouch , Lionel Rostaing , Olivier Epaulard , on behalf of INTEGRAL Study Group

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引用次数: 0

摘要

目的：SARS-CoV-2 mRNA疫苗的反应原性引起了对实体器官移植受者排斥风险的关注。我们探讨了被诊断为急性排斥反应的SOT受者是否曾在与因果关系一致的时间框架内接受过疫苗注射。方法：选取2020年至2022年期间所有诊断为急性排斥反应并曾接种过SARS-CoV-2疫苗的SOT接受者，分析疫苗接种与排斥反应之间的延迟是否恒定。结果：在45例确诊患者中，从最后一次接种SARS-CoV-2到排斥反应的中位延迟时间为102 d [IQR 48-178]；这种延迟的连续分布，没有可识别的时间模式，不利于疫苗接种在排斥反应中的作用。结论：接种SARS-CoV-2 mRNA不太可能引发SOT受者的排斥反应。

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Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants

Objectives

SARS-CoV-2 mRNA vaccine reactogenicity has raised concerns regarding the risk of rejection in solid organ transplant recipients. We explored whether SOT recipients diagnosed with acute rejection had previously received a vaccine injection within a timeframe consistent with a causal link.

Methods

We identified all SOT recipients with a diagnosis of acute rejection from 2020 to 2022 and who had previously received a SARS-CoV-2 vaccination, and analysed whether the delay between vaccination and rejection was constant.

Results

In the 45 identified patients, median delay between the last SARS-CoV-2 vaccination and the rejection was 102 days [IQR 48–178]; the continuous distribution of this delay, with no identifiable time pattern, is not in favor of a role of vaccination in rejection.

Conclusion

SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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