{"title":"优化多功能治疗核壳磁性纳米粒子（MNP@Au）中的金层，以提高核磁共振成像引导质子治疗系统的辐射剂量：蒙特卡罗模拟","authors":"Mohammadreza Parishan, Rasool Safari, Maryam Bordbar, Zahra Rakeb, Reza Faghihi","doi":"10.1016/j.radphyschem.2024.112477","DOIUrl":null,"url":null,"abstract":"Magnetic Resonance Imaging (MRI)-guided proton therapy has advanced significantly in pre-clinical stages. This study investigates the potential of multifunctional theranostic magnetic nanoparticles (MNPs) to enhance radiation dose while serving as MRI contrast agents. We propose MNP@Au nanoparticles, consisting of a magnetic core coated with a gold (Au) layer, and aim to optimize the Au layer thickness to maximize dose enhancement during proton therapy while preserving magnetic properties.","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"33 1","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimization of the gold layer in multifunctional theranostic core-shell magnetic nanoparticles (MNP@Au) for radiation dose enhancement in an MRI-guided proton therapy system: A Monte Carlo simulation\",\"authors\":\"Mohammadreza Parishan, Rasool Safari, Maryam Bordbar, Zahra Rakeb, Reza Faghihi\",\"doi\":\"10.1016/j.radphyschem.2024.112477\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Magnetic Resonance Imaging (MRI)-guided proton therapy has advanced significantly in pre-clinical stages. This study investigates the potential of multifunctional theranostic magnetic nanoparticles (MNPs) to enhance radiation dose while serving as MRI contrast agents. We propose MNP@Au nanoparticles, consisting of a magnetic core coated with a gold (Au) layer, and aim to optimize the Au layer thickness to maximize dose enhancement during proton therapy while preserving magnetic properties.\",\"PeriodicalId\":20861,\"journal\":{\"name\":\"Radiation Physics and Chemistry\",\"volume\":\"33 1\",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation Physics and Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.radphyschem.2024.112477\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Physics and Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.radphyschem.2024.112477","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Optimization of the gold layer in multifunctional theranostic core-shell magnetic nanoparticles (MNP@Au) for radiation dose enhancement in an MRI-guided proton therapy system: A Monte Carlo simulation
Magnetic Resonance Imaging (MRI)-guided proton therapy has advanced significantly in pre-clinical stages. This study investigates the potential of multifunctional theranostic magnetic nanoparticles (MNPs) to enhance radiation dose while serving as MRI contrast agents. We propose MNP@Au nanoparticles, consisting of a magnetic core coated with a gold (Au) layer, and aim to optimize the Au layer thickness to maximize dose enhancement during proton therapy while preserving magnetic properties.
期刊介绍：
Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.
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