无细胞脂肪提取物和富血小板纤维蛋白对实验性兔耳创面瘢痕成熟的影响。

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-12-17 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S489625

Zhenni Wei, Mingliang Zhang, Minjian Chen, Yong Song, Yi Wang

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引用次数: 0

摘要

背景：治疗增生性瘢痕已有多种方法；然而，一种最佳的处理方法仍有待建立。本研究旨在通过组织形态学分析，研究和比较无细胞脂肪提取物（CEFFE）和富血小板纤维蛋白（PRF）对增生性瘢痕形成的影响。方法：12只家兔随机分为4组。(CEFFE+PRF组，n=3；CEFFE组，n=3， PRF组，n=3， Control组，n=3)。建立耳增厚性瘢痕模型后，四组每只兔双耳分别注射CEFFE 0.05 mL/cm2 + PRF 0.05 mL/cm2、CEFFE 0.1 mL/cm2、PRF 0.1 mL/cm2、生理盐水0.1 mL/cm2。注射后第40天用苏木精-伊红和马松染色评价瘢痕升高指数和组织学分析。结果：CEFFE+PRF组预防病理性瘢痕形成的效果，在毛细血管计数、胶原组织、成纤维细胞计数、瘢痕升高指数等方面，均明显优于CEFFE组、PRF组和对照组(p讨论：CEFFE联合PRF是我们研究中预防增生性瘢痕形成最有效的治疗方法。

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Effects of Cell-Free Fat Extract and Platelet-Rich Fibrin on Scar Maturation in an Experimental Rabbit Ear Wound Model.

Background: Multiple methods have been used to treat hypertrophic scarring; however, an optimal treatment method remains to be established. We aimed to research and compare the effects of cell-free fat extract (CEFFE) and platelet-rich fibrin (PRF) on hypertrophic scar formation based on histomorphological analysis in this study.

Methods: Twelve rabbits were divided into four groups randomly. (CEFFE+PRF group, n=3; CEFFE group, n=3, PRF group, n=3 and Control group, n=3). After the ear hypertrophic scar model were established, the two ears of each rabbit in the four groups were injected with CEFFE 0.05 mL/cm² + PRF 0.05 mL/cm², CEFFE 0.1 mL/cm², PRF 0.1 mL/cm², and saline 0.1 mL/cm², respectively. The scar elevation index and histological analysis using hematoxylin-eosin and Masson staining were evaluated after injection on day 40.

Results: The CEFFE+PRF group was significantly more effective in the prevention of pathological scar formation than the CEFFE-only, PRF-only, and control groups in terms of capillary count, collagen organization, fibroblast count, and scar elevation index (p<0.05).

Discussion: CEFFE combined with PRF was the most effective treatment for the prevention of hypertrophic scar formation in our study.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.