The genus Fraxinus L. (Oleaceae): A review of botany, traditional and modern applications, phytochemistry, and bioactivity

Fraxinus L., a member of the Oleaceae family with approximately 60 species worldwide, is widely distributed in the warm temperate zone of the northern hemisphere. It is not only used as a folk medicine for treating various illnesses but is also documented in medical books. The traditional Chinese medicine "Qin Pi" originated from this genus and is known for its efficacy in treating conditions such as intestinal inflammation, redness and pain in the eyes, abomination of redness and leucorrhoea, and bacterial infections. This paper aims to fill the gap in the existing literature by providing a comprehensive review and critical analysis of the Fraxinus genus plant. The discussion in this paper covers various aspects of the plant, including its botany, traditional and modern applications, phytochemistry, bioactivity, role in ecosystems, phytogenetic evolution, economic benefits, and future challenges. By synthesizing this information, the review aims to offer valuable insights for the advancement, utilization, and further research of the Fraxinus spp.. Phytochemical studies have identified a total of 281 chemical constituents in Fraxinus spp., including secoiridoids, coumarins, and flavonoids. These Fraxinus spp. plants exhibit a wide range of biological activities, such as anti-inflammatory, antioxidant, and antibacterial properties. Furthermore, this paper delves into potential research directions within the genus and addresses the challenges associated with achieving a comprehensive understanding of Fraxinus spp. This paper provides a comprehensive overview of Fraxinus spp., highlighting their bioactivity mechanism and the opportunity to facilitate the advancement of new pharmaceuticals.