SARS-CoV-2对男性性功能影响的最新综述

Radheshyam Pal, Prashant Kumar, Ekta Khare, Amit Anand, Tinku Kumar, Rohit Malik, Vatan Chaudhary, Mithun Bhowmick, Sumel Ashique
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摘要

SARS-CoV-2,也被称为冠状病毒,引起SARS-CoV-2或严重急性呼吸系统综合征,这是一种高度传染性疾病,已在全球迅速传播,使医疗系统紧张,并导致大量死亡。有趣的是,SARS-CoV-2显示出性别差异,男性死亡率更高,病例也比女性严重。值得注意的是,在中度到重度疾病期间,男性生殖系统可能特别容易受到损害,这与睾丸炎和勃起功能障碍有关。此外,在从病毒中恢复的活着的患者的睾丸和阴茎组织以及死于该病毒的男性的尸检分析中都发现了SARS-CoV-2病毒颗粒。对于从SARS-CoV-2中康复的男性来说,性传播不是一个大问题,尽管中度至重度感染可能对男性生殖健康产生不利影响。这包括生殖细胞和间质细胞的消耗,导致精子形成减少,潜在地减少男性性激素的释放。这些副作用可能会导致不孕和性功能障碍等问题,这些问题越来越受到想要怀孕或需要辅助生殖的夫妇的关注。许多研究从各种角度研究了SARS-CoV-2对男性生殖健康的影响。本综述的目的是对SARS-CoV-2如何影响男性生殖健康进行概述。
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Repercussion of SARS-CoV-2 on the Sexual Function in Males Updated Review.

SARS-CoV-2, also called coronavirus causes SARS-CoV-2 or severe acute respir-atory syndrome, a highly transmissible disease that has rapidly spread worldwide, straining healthcare systems and leading to a substantial number of fatalities. Interestingly, SARS-CoV-2 has revealed a gender difference, with males dying at a greater rate and with more severe cases than women. It's worth noting that the male reproductive system might be par-ticularly susceptible to damage during periods of moderate to severe sickness, which has been linked to cases of orchitis and erectile dysfunction. Furthermore, SARS-CoV-2 virus particles have been found in the tissues of the testes and penile of both living patients who have recov-ered from the virus and in post-mortem analyses of males who have died from it. For males who have recovered from SARS-CoV-2, sexual transmission is not a big concern, even though moderate to severe infections may have detrimental effects on male reproductive health. This includes the depletion of germ cells and Leydig cells that leads to a decrease in the formation of sperm, potentially decreasing the release of male sex hormones. These ad-verse effects may result in issues such as infertility and sexual dysfunction, which are of growing concern for couples looking to conceive or those in need of assisted reproduction. Numerous investigations have examined SARS-CoV-2's effects on male reproductive health from a variety of perspectives. The purpose of this review is to give a general summary of how SARS-CoV-2 has affected male reproductive health.

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