唾液microRNA-93和microRNA-412-3p在口腔扁平苔藓中的致癌潜力:一项病例对照研究。

IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE BDJ Open Pub Date : 2024-12-23 DOI:10.1038/s41405-024-00278-5
Moataz M ELHefny, Inas A Korien, Weam Am Rashwan, Olfat G Shaker
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引用次数: 0

摘要

背景:口腔扁平苔藓是最常见的慢性粘膜皮肤病之一。它被归类为潜在的恶性病变。许多microrna可以作为疾病及其恶性转化的生物学标记物。本研究旨在检测口腔扁平苔藓患者、诊断为口腔鳞状细胞癌患者和健康对照者中microRNA-93和microRNA-412-3p的表达。方法:将60例患者分为3组;每组20例。第一组为口腔扁平苔藓患者,第二组为健康对照组,第三组为口腔鳞状细胞癌患者。所有这些病人都是从开罗大学卡斯尔艾尼医院的病人中选出的。在充分诊断并符合我们的资格标准后,采集每位患者的唾液样本,测量microRNA-93和microRNA-412-3p的浓度。结果:microRNA-93和microrna -412-3p在口腔鳞状细胞癌患者中表达水平均高于口腔苔藓患者,且对口腔扁平苔藓和口腔鳞状细胞癌均有较高的敏感性、特异性和诊断准确性。结论:MicroRNA-93和microrna -412-3p可作为口腔扁平苔藓的诊断标志物和潜在的致癌因素。
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The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: a case-control study.

Background: Oral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation. The aim of the study to measure the expression of microRNA-93 and microRNA-412-3p in Oral Lichen Planus patients, patients diagnosed as Oral Squamous Cell Carcinoma and healthy controls.

Methodology: A total of 60 patients were divided into 3 groups; each group contains 20 patients. Group I for Oral Lichen Planus patients, group II for healthy controls and group III for Oral Squamous cell carcinoma patients. All of these patients were chosen from those attending Kasr Al-Einy hospital, Cairo University. After full diagnosis and matching of our eligibility criteria, saliva sample was taken from each patient to measure the concentration of microRNA-93 and microRNA-412-3p.

Results: Both microRNA-93 and miceoRNA-412-3p were upregulated in Oral Squamous cell carcinoma patients than Oral Lichen patients than controls and both of them had great sensitivity, specificity and diagnostic accuracy for both Oral Lichen Planus and Oral Squamous cell carcinoma.

Conclusion: MicroRNA-93 and micriRNA-412-3p can be used as diagnostic markers and for the oncogenic potential of Oral Lichen Planus.

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来源期刊
BDJ Open
BDJ Open Dentistry-Dentistry (all)
CiteScore
3.70
自引率
3.30%
发文量
34
审稿时长
30 weeks
期刊最新文献
In vitro evaluation of human enamel remineralization after treatment with Ginger, Ashwaganda and Maca herbal dentifrices versus commercially available fluoride containing dentifrice. Predictive factors for insertion torque values in transalveolar sinus lift procedures. Correction: Posture analysis during tooth extraction. Correction: Efficacy of oral irrigators compared to other interdental aids for managing peri-implant diseases: a systematic review. Evaluation of magnesium-based scaffolds fabricated using a modified sintering technique and two types of space holding agents (in vitro study).
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