{"title":"高效液相色谱串联质量选择检测法测定血液和尿液中莫替尼定含量的研究","authors":"A V Vasilenko, A B Melentyev, O N Dvorskaya","doi":"10.17116/sudmed20246706142","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Development and validation of a sensitive and rapid method for moxonidine detection and quantification in blood and/or urine in clinical toxicology and forensic chemistry.</p><p><strong>Material and methods: </strong>The method included the following stages: acetonitrile extraction, centrifugation, identification, and quantitative analysis of moxonidine in cadaveric blood and/or urine by high-performance liquid chromatography with a triple quadrupole mass spectrometer.</p><p><strong>Results: </strong>The method was validated by the following parameters: limit of detection, limit of quantification, linearity, trueness, and precision. Over the entire range of determined concentrations, the relative standard deviation did not exceed 6%.</p><p><strong>Conclusion: </strong>The obtained results allow future use of this method to detect cases of moxonidine poisoning.</p>","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":"67 6","pages":"42-47"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Development of a method for moxonidine quantification in blood and urine by high-performance liquid chromatography with tandem mass-selective detection].\",\"authors\":\"A V Vasilenko, A B Melentyev, O N Dvorskaya\",\"doi\":\"10.17116/sudmed20246706142\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Development and validation of a sensitive and rapid method for moxonidine detection and quantification in blood and/or urine in clinical toxicology and forensic chemistry.</p><p><strong>Material and methods: </strong>The method included the following stages: acetonitrile extraction, centrifugation, identification, and quantitative analysis of moxonidine in cadaveric blood and/or urine by high-performance liquid chromatography with a triple quadrupole mass spectrometer.</p><p><strong>Results: </strong>The method was validated by the following parameters: limit of detection, limit of quantification, linearity, trueness, and precision. Over the entire range of determined concentrations, the relative standard deviation did not exceed 6%.</p><p><strong>Conclusion: </strong>The obtained results allow future use of this method to detect cases of moxonidine poisoning.</p>\",\"PeriodicalId\":35704,\"journal\":{\"name\":\"Sudebno-Meditsinskaya Ekspertisa\",\"volume\":\"67 6\",\"pages\":\"42-47\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sudebno-Meditsinskaya Ekspertisa\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17116/sudmed20246706142\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sudebno-Meditsinskaya Ekspertisa","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/sudmed20246706142","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
[Development of a method for moxonidine quantification in blood and urine by high-performance liquid chromatography with tandem mass-selective detection].
Objective: Development and validation of a sensitive and rapid method for moxonidine detection and quantification in blood and/or urine in clinical toxicology and forensic chemistry.
Material and methods: The method included the following stages: acetonitrile extraction, centrifugation, identification, and quantitative analysis of moxonidine in cadaveric blood and/or urine by high-performance liquid chromatography with a triple quadrupole mass spectrometer.
Results: The method was validated by the following parameters: limit of detection, limit of quantification, linearity, trueness, and precision. Over the entire range of determined concentrations, the relative standard deviation did not exceed 6%.
Conclusion: The obtained results allow future use of this method to detect cases of moxonidine poisoning.
期刊介绍：
The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.
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