人类传染病的单基因景观。

IF 11.4 1区医学 Q1 ALLERGY Journal of Allergy and Clinical Immunology Pub Date : 2024-12-24 DOI:10.1016/j.jaci.2024.12.1078

Stéphanie Boisson-Dupuis,Paul Bastard,Vivien Béziat,Jacinta Bustamante,Aurélie Cobat,Emmanuelle Jouanguy,Anne Puel,Jérémie Rosain,Qian Zhang,Shen-Ying Zhang,Bertrand Boisson

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引用次数: 0

摘要

已知的单基因先天性免疫缺陷的范围正在增加，某些疾病是特定和狭窄范围传染病的基础。这些疾病揭示了这些感染在各种情况下发生的核心机制，包括遗传性和获得性免疫缺陷，从而描绘了对相应病原体的保护性免疫的基本机制。这些发现还具有医学意义，有助于诊断和改善对有疾病风险的个体的管理。

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The Monogenic Landscape of Human Infectious Diseases.

The spectrum of known monogenic inborn errors of immunity is growing, with certain disorder underlying a specific and narrow range of infectious diseases. These disorders reveal the core mechanisms by which these infections occur in various settings, including inherited and acquired immunodeficiencies, thereby delineating the essential mechanisms of protective immunity to the corresponding pathogens. These findings also have medical implications, facilitating diagnosis and improving the management of individuals at risk of disease.

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来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.

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