对含甲基丙烯酸酯的指甲产品的接触性过敏:缺乏欧盟立法的影响。代表欧洲环境接触性皮炎研究小组(EECDRG)进行的审计。

IF 4.8 1区 医学 Q2 ALLERGY Contact Dermatitis Pub Date : 2024-12-25 DOI:10.1111/cod.14745
S. Mark Wilkinson, Olivier Aerts, Tove Agner, Magnus Bruze, Richard Brans, Caterina Foti, Ana Maria Giménez-Arnau, Luca Stingeni, Cecilia Svedman
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引用次数: 0

摘要

背景:目前流行使用含有甲基丙烯酸酯的指甲化妆品,可诱发过敏性接触性皮炎。欧盟(EU)于2021年出台了旨在阻止其发展的立法。目的:评估立法实施前后2-甲基丙烯酸羟乙基酯(HEMA)接触性过敏的患病率和暴露情况。方法:在立法前和立法后2年,通过7个欧洲中心对HEMA进行补丁测试进行回顾性审计。结果:在2016年至2023年的基线系列中,共有26297例患者接受了HEMA检测。女性对所有来源的HEMA接触性过敏发生率为2.82%,男性为0.34%。指甲相关接触性过敏的患病率从2016年的0.91%(2个中心)上升到2017年的0.99%(3个中心);2018年为1.24%(5个中心);2019年为1.23%(6个中心);2020年达到1.36%(7个中心);2021年1.30%(7个中心);2022年为1.52%(7个中心),2023年为1.98%(7个中心)。指甲化妆品接触性致HEMA过敏占所有职业性皮肤病的3.4%。结论:欧盟立法似乎没有对控制甲化妆品中甲基丙烯酸酯引起的过敏性接触性皮炎产生预期的影响。迫切需要重新审视消费者安全科学委员会(SCCS)的意见,重新考虑甲基丙烯酸酯的暴露和它们之间的交叉反应。需要制定和实施一项战略,以更好地控制当前的疫情。
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Contact Allergy to Methacrylate Containing Nail Products: Lack of Impact of EU Legislation. An Audit on Behalf of the European Environmental Contact Dermatitis Research Group (EECDRG)

Background

There is a current fashion for the use of methacrylate-containing nail cosmetics that can induce allergic contact dermatitis. European Union (EU) legislation was introduced in 2021 that had the aim of preventing its development.

Objectives

To assess prevalence and exposures causing contact allergy to 2-hydroxyethyl methacrylate (HEMA) prior to and following implementation of the legislation.

Methods

A retrospective audit was conducted by 7 European centres patch testing to HEMA prior to the legislation and for 2 years afterwards.

Results

A total of 26 297 patients were tested to HEMA in the baseline series between 2016 and 2023. The prevalence of contact allergy to HEMA from all sources amongst females was 2.82% compared to 0.34% amongst males.

The prevalence of nail related contact allergy rose from 0.91% in 2016 (2 centres) to: 0.99% in 2017 (3 centres); 1.24% in 2018 (5 centres); 1.23% in 2019 (6 centres); 1.36% in 2020 (7 centres); 1.30% in 2021 (7 centres); 1.52% in 2022 (7 centres) and 1.98% in 2023 (7 centres).

Contact allergy to HEMA from exposure to nail cosmetics accounted for 3.4% of all occupational skin disease.

Conclusions

EU legislation appears not to have had the intended impact on controlling allergic contact dermatitis from methacrylates in nail cosmetics. There is an urgent need to revisit Scientific Committee on Consumer Safety (SCCS) opinion to reconsider exposure to methacrylates and cross-reactions between them. A strategy needs to be developed and implemented to better control the current outbreak.

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来源期刊
Contact Dermatitis
Contact Dermatitis 医学-过敏
CiteScore
4.60
自引率
30.90%
发文量
227
审稿时长
4-8 weeks
期刊介绍: Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".
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