细菌外膜囊泡(OMV)包封二氧化钛纳米粒子:在口腔癌治疗中增强放疗和免疫调节的双重作用策略。

IF 4.4 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Nanomaterials Pub Date : 2024-12-20 DOI:10.3390/nano14242045
Shun-An Kan, Li-Wen Zhang, Yu-Chi Wang, Cheng-Yu Chiang, Mei-Hsiu Chen, Shih-Hao Huang, Ming-Hong Chen, Tse-Ying Liu
{"title":"细菌外膜囊泡(OMV)包封二氧化钛纳米粒子:在口腔癌治疗中增强放疗和免疫调节的双重作用策略。","authors":"Shun-An Kan, Li-Wen Zhang, Yu-Chi Wang, Cheng-Yu Chiang, Mei-Hsiu Chen, Shih-Hao Huang, Ming-Hong Chen, Tse-Ying Liu","doi":"10.3390/nano14242045","DOIUrl":null,"url":null,"abstract":"<p><p>Oral squamous-cell carcinoma (OSCC) poses significant treatment challenges due to its high recurrence rates and the limitations of current therapies. Titanium dioxide (TiO<sub>2</sub>) nanoparticles are promising radiosensitizers, while bacterial outer membrane vesicles (OMVs) are known for their immunomodulatory properties. This study investigates the potential of OMV-encapsulated TiO<sub>2</sub> nanoparticles (TiO<sub>2</sub>@OMV) to combine these effects for improved OSCC treatment. TiO<sub>2</sub> nanoparticles were synthesized using a hydrothermal method and encapsulated within OMVs derived from Escherichia coli. The TiO<sub>2</sub>@OMV carriers were evaluated for their ability to enhance radiosensitivity and stimulate immune responses in OSCC cell lines. Reactive oxygen species (ROS) production, macrophage recruitment, and selective cytotoxicity toward cancer cells were assessed. TiO<sub>2</sub>@OMV demonstrated significant radiosensitization and immune activation compared to unencapsulated TiO<sub>2</sub> nanoparticles. The system selectively induced cytotoxicity in OSCC cells, sparing normal cells, and enhanced ROS generation and macrophage-mediated antitumor responses. This study highlights TiO<sub>2</sub>@OMV as a dual-action therapeutic platform that synergizes radiotherapy and immunomodulation, offering a targeted and effective strategy for OSCC treatment. The approach could improve therapeutic outcomes and reduce the adverse effects associated with conventional therapies.</p>","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 24","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678132/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bacterial Outer Membrane Vesicle (OMV)-Encapsulated TiO<sub>2</sub> Nanoparticles: A Dual-Action Strategy for Enhanced Radiotherapy and Immunomodulation in Oral Cancer Treatment.\",\"authors\":\"Shun-An Kan, Li-Wen Zhang, Yu-Chi Wang, Cheng-Yu Chiang, Mei-Hsiu Chen, Shih-Hao Huang, Ming-Hong Chen, Tse-Ying Liu\",\"doi\":\"10.3390/nano14242045\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Oral squamous-cell carcinoma (OSCC) poses significant treatment challenges due to its high recurrence rates and the limitations of current therapies. Titanium dioxide (TiO<sub>2</sub>) nanoparticles are promising radiosensitizers, while bacterial outer membrane vesicles (OMVs) are known for their immunomodulatory properties. This study investigates the potential of OMV-encapsulated TiO<sub>2</sub> nanoparticles (TiO<sub>2</sub>@OMV) to combine these effects for improved OSCC treatment. TiO<sub>2</sub> nanoparticles were synthesized using a hydrothermal method and encapsulated within OMVs derived from Escherichia coli. The TiO<sub>2</sub>@OMV carriers were evaluated for their ability to enhance radiosensitivity and stimulate immune responses in OSCC cell lines. Reactive oxygen species (ROS) production, macrophage recruitment, and selective cytotoxicity toward cancer cells were assessed. TiO<sub>2</sub>@OMV demonstrated significant radiosensitization and immune activation compared to unencapsulated TiO<sub>2</sub> nanoparticles. The system selectively induced cytotoxicity in OSCC cells, sparing normal cells, and enhanced ROS generation and macrophage-mediated antitumor responses. This study highlights TiO<sub>2</sub>@OMV as a dual-action therapeutic platform that synergizes radiotherapy and immunomodulation, offering a targeted and effective strategy for OSCC treatment. The approach could improve therapeutic outcomes and reduce the adverse effects associated with conventional therapies.</p>\",\"PeriodicalId\":18966,\"journal\":{\"name\":\"Nanomaterials\",\"volume\":\"14 24\",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678132/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomaterials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.3390/nano14242045\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomaterials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.3390/nano14242045","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

口腔鳞状细胞癌(OSCC)由于其高复发率和现有治疗方法的局限性,对治疗提出了重大挑战。二氧化钛(TiO2)纳米粒子是很有前途的放射增敏剂,而细菌外膜囊泡(omv)则以其免疫调节特性而闻名。本研究探讨了omv包封的TiO2纳米颗粒(TiO2@OMV)在改善OSCC处理方面的潜力。采用水热法合成TiO2纳米颗粒,并将其封装在大肠杆菌衍生的omv中。评估TiO2@OMV携带者增强OSCC细胞系放射敏感性和刺激免疫反应的能力。评估了活性氧(ROS)的产生、巨噬细胞的募集和对癌细胞的选择性细胞毒性。与未封装的TiO2纳米颗粒相比,TiO2@OMV表现出显著的放射致敏性和免疫激活。该系统选择性地诱导OSCC细胞的细胞毒性,保留正常细胞,并增强ROS生成和巨噬细胞介导的抗肿瘤反应。本研究强调TiO2@OMV作为一个双重作用的治疗平台,可以协同放疗和免疫调节,为OSCC的治疗提供有针对性和有效的策略。该方法可以改善治疗效果,减少与传统治疗相关的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Bacterial Outer Membrane Vesicle (OMV)-Encapsulated TiO2 Nanoparticles: A Dual-Action Strategy for Enhanced Radiotherapy and Immunomodulation in Oral Cancer Treatment.

Oral squamous-cell carcinoma (OSCC) poses significant treatment challenges due to its high recurrence rates and the limitations of current therapies. Titanium dioxide (TiO2) nanoparticles are promising radiosensitizers, while bacterial outer membrane vesicles (OMVs) are known for their immunomodulatory properties. This study investigates the potential of OMV-encapsulated TiO2 nanoparticles (TiO2@OMV) to combine these effects for improved OSCC treatment. TiO2 nanoparticles were synthesized using a hydrothermal method and encapsulated within OMVs derived from Escherichia coli. The TiO2@OMV carriers were evaluated for their ability to enhance radiosensitivity and stimulate immune responses in OSCC cell lines. Reactive oxygen species (ROS) production, macrophage recruitment, and selective cytotoxicity toward cancer cells were assessed. TiO2@OMV demonstrated significant radiosensitization and immune activation compared to unencapsulated TiO2 nanoparticles. The system selectively induced cytotoxicity in OSCC cells, sparing normal cells, and enhanced ROS generation and macrophage-mediated antitumor responses. This study highlights TiO2@OMV as a dual-action therapeutic platform that synergizes radiotherapy and immunomodulation, offering a targeted and effective strategy for OSCC treatment. The approach could improve therapeutic outcomes and reduce the adverse effects associated with conventional therapies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nanomaterials
Nanomaterials NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
8.50
自引率
9.40%
发文量
3841
审稿时长
14.22 days
期刊介绍: Nanomaterials (ISSN 2076-4991) is an international and interdisciplinary scholarly open access journal. It publishes reviews, regular research papers, communications, and short notes that are relevant to any field of study that involves nanomaterials, with respect to their science and application. Thus, theoretical and experimental articles will be accepted, along with articles that deal with the synthesis and use of nanomaterials. Articles that synthesize information from multiple fields, and which place discoveries within a broader context, will be preferred. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental or methodical details, or both, must be provided for research articles. Computed data or files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Nanomaterials is dedicated to a high scientific standard. All manuscripts undergo a rigorous reviewing process and decisions are based on the recommendations of independent reviewers.
期刊最新文献
A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe2O3 for Toxicity Detection of Drinking Water Disinfection Byproducts. AgGaS2 and Derivatives: Design, Synthesis, and Optical Properties. Anisotropic Elasticity, Spin-Orbit Coupling, and Topological Properties of ZrTe2 and NiTe2: A Comparative Study for Spintronic and Nanoscale Applications. Controllable Nano-Crystallization in Fluoroborosilicate Glass Ceramics for Broadband Visible Photoluminescence. A Cu(I)-Based MOF with Nonlinear Optical Properties and a Favorable Optical Limit Threshold.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1