{"title":"慢性肾脏疾病患者短疗程高剂量乙型肝炎疫苗免疫原性研究——山西省，中国，2019-2020。","authors":"Linying Gao, Xufeng Cui, Xinyuan Mo, Zhaoyue Men, Xiuyang Xu, Tian Yao, Jianmin Wang, Hongting Liu, Hongping Guo, Guowei Chai, Liming Liu, Fuzhen Wang, Xiaofeng Liang, Suping Wang, Yongliang Feng","doi":"10.46234/ccdcw2024.264","DOIUrl":null,"url":null,"abstract":"<p><strong>What is already known about this topic?: </strong>As one of the populations at high risk of hepatitis B virus (HBV) infection, patients with chronic kidney disease (CKD) require rapid and effective development of hepatitis B surface antibodies (anti-HBs).</p><p><strong>What is added by this report?: </strong>The short-course, high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen, achieving a seroconversion rate of 88.5%, a high-response rate of 64.1%, and anti-HBs geometric mean concentrations of 824.1 mIU/mL.</p><p><strong>What are the implications for public health practice?: </strong>The short-course, high-dose regimen represents an effective rapid immunization strategy for CKD patients, particularly when administered prior to immunosuppressive therapy. This study provides compelling evidence for optimizing immunization protocols in the CKD population.</p>","PeriodicalId":69039,"journal":{"name":"中国疾病预防控制中心周报","volume":"6 50","pages":"1331-1336"},"PeriodicalIF":4.3000,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673178/pdf/","citationCount":"0","resultStr":"{\"title\":\"Immunogenicity of Short-Course, High-Dose Hepatitis B Vaccination in Patients with Chronic Kidney Disease - Shanxi Province, China, 2019-2020.\",\"authors\":\"Linying Gao, Xufeng Cui, Xinyuan Mo, Zhaoyue Men, Xiuyang Xu, Tian Yao, Jianmin Wang, Hongting Liu, Hongping Guo, Guowei Chai, Liming Liu, Fuzhen Wang, Xiaofeng Liang, Suping Wang, Yongliang Feng\",\"doi\":\"10.46234/ccdcw2024.264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>What is already known about this topic?: </strong>As one of the populations at high risk of hepatitis B virus (HBV) infection, patients with chronic kidney disease (CKD) require rapid and effective development of hepatitis B surface antibodies (anti-HBs).</p><p><strong>What is added by this report?: </strong>The short-course, high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen, achieving a seroconversion rate of 88.5%, a high-response rate of 64.1%, and anti-HBs geometric mean concentrations of 824.1 mIU/mL.</p><p><strong>What are the implications for public health practice?: </strong>The short-course, high-dose regimen represents an effective rapid immunization strategy for CKD patients, particularly when administered prior to immunosuppressive therapy. This study provides compelling evidence for optimizing immunization protocols in the CKD population.</p>\",\"PeriodicalId\":69039,\"journal\":{\"name\":\"中国疾病预防控制中心周报\",\"volume\":\"6 50\",\"pages\":\"1331-1336\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-12-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673178/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国疾病预防控制中心周报\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.46234/ccdcw2024.264\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国疾病预防控制中心周报","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.46234/ccdcw2024.264","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Immunogenicity of Short-Course, High-Dose Hepatitis B Vaccination in Patients with Chronic Kidney Disease - Shanxi Province, China, 2019-2020.
What is already known about this topic?: As one of the populations at high risk of hepatitis B virus (HBV) infection, patients with chronic kidney disease (CKD) require rapid and effective development of hepatitis B surface antibodies (anti-HBs).
What is added by this report?: The short-course, high-dose regimen of hepatitis B vaccination rapidly induced comparable immunological responses to the routine regimen, achieving a seroconversion rate of 88.5%, a high-response rate of 64.1%, and anti-HBs geometric mean concentrations of 824.1 mIU/mL.
What are the implications for public health practice?: The short-course, high-dose regimen represents an effective rapid immunization strategy for CKD patients, particularly when administered prior to immunosuppressive therapy. This study provides compelling evidence for optimizing immunization protocols in the CKD population.
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