与颌骨母细胞瘤复发风险和无复发生存率相关的因素:单中心回顾性分析。

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2024-12-30 DOI:10.1007/s10006-024-01321-3
Rathindra Nath Bera, Preeti Tiwari
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引用次数: 0

摘要

目的:成釉细胞瘤是一种起源于牙源性上皮的良性肿瘤,全球发病率约为每百万人每年0.5例。成釉细胞瘤的总复发率为55% -90%。在这项回顾性研究中,我们分析了颌骨成釉细胞瘤复发和无复发生存的相关因素。方法:从病历目录中回顾性回顾10年的病历。所有的人口统计数据、诊断方式、临床表现、放射学、管理和组织学数据都被考虑在内。采用Kaplan Meir估计评估复发率,采用Cox回归分析(单因素和多因素)评估优势比,找出可能影响复发风险的因素及影响无复发生存的因素。ROC曲线(Receiver Operating Characteristic)用于寻找预测复发的病灶大小的最佳截断点。结果p值:75例患者复发,中位随访65个月。总体5年RFS为19.5%。常规成釉细胞瘤、皮层/软组织浸润、保守治疗和肿瘤大小≥4 cm是复发的独立预测因素。结论:对于常规成釉细胞瘤≥4 cm且伴有皮层/软组织浸润者,首选积极治疗。
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Factors related to risk of recurrence and recurrence free survival in ameloblastoma of the Jaws: A single centre retrospective analysis.

Purpose: Ameloblastoma is a benign tumor originating from odontogenic epithelium with a global incidence of about 0.5 cases per million persons per year. The overall recurrence rate of ameloblastomas range from 55% -90%. In this retrospective study we have analyzed the factors associated with recurrence and recurrence free survival in ameloblastoma of the jaws.

Methods: Retrospective chart review of 10 years was done from records directory. All demographic data, data on diagnostic modalities, clinical presentations, radiology, management and histology were taken into consideration. Kaplan Meir estimator was used to evaluate recurrence rate and Cox regression analysis (univariate and multivariate) was used to evaluate the odds ratio to find out the possible factors influencing risk of recurrence and influence recurrence free survival. ROC curve (Receiver Operating Characteristic) was used to find out the optimal cut off point for size of the lesion in predicting recurrence. A p value of < 0.05 was considered statistically significant at 95% confidence interval.

Results: A total of 75 patients had recurrence with a median follow up of 65 months. The overall 5 year RFS was 19.5%. Conventional ameloblastomas, cortical/ soft tissue invasion, conservative treatment and tumor size ≥ 4 cm were independent predictors of recurrence.

Conclusion: Aggressive treatment is preferred for conventional ameloblastomas ≥ 4 cm with cortical/ soft tissue invasion.

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来源期刊
Oral and Maxillofacial Surgery-Heidelberg
Oral and Maxillofacial Surgery-Heidelberg DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.20
自引率
5.60%
发文量
118
期刊介绍: Oral & Maxillofacial Surgery founded as Mund-, Kiefer- und Gesichtschirurgie is a peer-reviewed online journal. It is designed for clinicians as well as researchers.The quarterly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery and interdisciplinary aspects of cranial, facial and oral diseases and their management. The journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery as well as supporting specialties. Practice-oriented articles help improve the methods used in oral and maxillofacial surgery.Every aspect of oral and maxillofacial surgery is fully covered through a range of invited review articles, clinical and research articles, technical notes, abstracts, and case reports. Specific topics are: aesthetic facial surgery, clinical pathology, computer-assisted surgery, congenital and craniofacial deformities, dentoalveolar surgery, head and neck oncology, implant dentistry, oral medicine, orthognathic surgery, reconstructive surgery, skull base surgery, TMJ and trauma.Time-limited reviewing and electronic processing allow to publish articles as fast as possible. Accepted articles are rapidly accessible online.Clinical studies submitted for publication have to include a declaration that they have been approved by an ethical committee according to the World Medical Association Declaration of Helsinki 1964 (last amendment during the 52nd World Medical Association General Assembly, Edinburgh, Scotland, October 2000). Experimental animal studies have to be carried out according to the principles of laboratory animal care (NIH publication No 86-23, revised 1985).
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