利用可打印弹性电子皮肤无创预测心血管疾病。

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2025-01-02 DOI:10.1002/adhm.202404056
Muthamil Selvan T, Titash Mondal
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引用次数: 0

摘要

缺乏对心血管疾病(CVC)的及时预后导致全球死亡率上升。目前,可用的技术仅限于医疗设施,需要专家的干预。在社会经济因素的推动下,这往往妨碍及时治疗。因此,这种疾病超越了无法治愈的并发症。在这种情况下,即时诊断工具可以帮助在早期阶段进行预后。尽管有这样的工具可用,但必须以经济实惠的方式开发简单的制造技术,并且应该具有简单的读数和分析模块来监测CVC。据此,报道了无溶剂制造的基于碳纳米管电子皮肤的模板可打印液体弹性体应变传感器,该传感器能够准确检测与CVC相关的脉冲(不同位置)和动脉增强指数、刚度指数等参数。庞加莱图是根据记录数据绘制的,测量心率变异性,这是与死亡率相关的一个关键指标。由于惊人的线性度,测量因子234.26,85 ms的快速响应时间(从脉冲数据测量)和循环稳定性(超过500个周期),有助于轻松检测重要参数。此外,该传感器贴片还展示了其在不同实时动脉状况下使用袖带压力应用获取脉搏波的能力。
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Prognosis of Cardiovascular Conditions Noninvasively Using Printable Elastomeric Electronic Skin.

Lack of timely prognosis of cardiovascular condition (CVC) is resulting in increased mortality across the globe. Currently, available techniques are confined to medical facilities and need the intervention of specialists. Frequently, this impedes timely treatment, driven by socioeconomic factors. Consequently, the disease transcends toward incurable complications. In such a scenario, point-of-care diagnostic tools can help with prognosis at an early stage. Albeit there are such tools available, it is imperative to develop affordably in uncomplicated manufacturing techniques and should have simple readout and analysis modules for monitoring CVC. Accordingly, the solvent-free manufacturing of stencil printable liquid elastomer-carbon nanotube electronic skin-based strain sensor, capable of accurately detecting pulse (at different positions) and other parameters like augmentation index and stiffness index of artery related to the CVC, is reported. The Poincare plot, derived from the recorded data, measures heart rate variability, a key indicator linked to mortality. Thanks to the staggering linearity, gauge factor of 234.26, fast response time of 85 ms (measured from pulse data), and cyclic stability (over 500 cycles), assist in the ease of detection of vital parameters. Furthermore, the sensor patch demonstrates its capability to acquire pulse waves under different real-time artery conditions using cuff-based pressure applications.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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