控制流行病的大规模检测策略的理论分析

IF 2 4区 数学 Q2 BIOLOGY Bulletin of Mathematical Biology Pub Date : 2025-01-03 DOI:10.1007/s11538-024-01387-w
Michela Sabbatino, Simone De Reggi, Andrea Pugliese
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引用次数: 0

摘要

一些国家遏制COVID-19流行的战略之一是检测和隔离政策,通常与接触者追踪相结合。这些策略已经在几个模拟模型中进行了检验,但据我们所知,在简单的流行病模型中缺乏对其有效性的理论分析。在本文中,我们提出了SIR或SEIR型的四种流行病模型,其中假设在固定时间对整个人群(或部分人群)进行检测,如果呈阳性,则进行隔离。在这样的战略下,我们找到了流行病灭绝的条件;对于这些类型的模型,我们提供了r0的适当定义,可以用解析或数值方法计算。最后,我们在数值上表明,在较大的参数范围内,SIR模型的最终尺寸关系近似地适用于四种模型。
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A Theoretical Analysis of Mass Testing Strategies to Control Epidemics.

One of the strategies used in some countries to contain the COVID-19 epidemic has been the test-and-isolate policy, generally coupled with contact tracing. Such strategies have been examined in several simulation models, but a theoretical analysis of their effectiveness in simple epidemic model is, to our knowledge, missing. In this paper, we present four epidemic models of either SIR or SEIR type, in which it is assumed that at fixed times the whole population (or a part of the population) is tested and, if positive, isolated. We find the conditions for an epidemic to go extinct under such a strategy; for these types of models we provide an appropriate definition of R 0 , that can be computed either analytically or numerically. Finally, we show numerically that the final-size relation of SIR models approximately holds for the four models, over a large parameter range.

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来源期刊
CiteScore
3.90
自引率
8.60%
发文量
123
审稿时长
7.5 months
期刊介绍: The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including: Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations Research in mathematical biology education Reviews Commentaries Perspectives, and contributions that discuss issues important to the profession All contributions are peer-reviewed.
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