体成分测量作为犬尾骨肉瘤立体定向放射治疗结果的预测变量。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2025-01-02 DOI:10.1111/vco.13037
Johnny Altwal, Lynn Griffin, Tiffany Wormhoudt Martin
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引用次数: 0

摘要

通过计算机断层扫描(CT)获得的身体成分测量(BCM)已被用作人类肿瘤患者生存、肿瘤复发和手术后感染的预测指标。目前还没有关于使用BCM来预测狗患癌症的结果的报道。据推测,BCM升高会对因癌症而变弱的骨骼造成额外的压力。犬尾骨肉瘤(OSA)立体定向放射治疗后的病理性骨折往往导致截肢或安乐死。需要更多的工具来更好地预测裂缝发展的风险。我们的目的是确定BCM与自然发生的OSA犬的病理性骨折和/或生存时间之间是否存在任何关系。纳入47只确诊OSA和全身CT前sbrt的狗。评估了几个BCM,包括腹部体积、内脏脂肪组织体积、全身体积、全身脂肪组织体积、第13胸椎体中外轴肌归一化横截面积、脂肪组织和外轴肌的衰减。无bcm与生存时间相关。全身体积(cm3)与骨折的发生显著正相关。没有其他BCM与骨折的发生相关。我们患者亚群的腹部体积(cm3)与全身体积呈正相关,内脏脂肪组织体积(cm3)与全身脂肪组织体积(cm3)呈正相关。需要进一步的研究来验证这些发现是否可以在更大的样本量和前瞻性环境中复制。
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Body Composition Measurements as Predictive Variables for Outcomes of Canine Appendicular Osteosarcoma Treated With Stereotactic Body Radiation Therapy.

Body composition measurements (BCM), obtained via computed tomography (CT), have been used as predictors of survival, tumour recurrence, and post-surgical infections in human oncology. There are no reports on using BCM to predict outcomes of dogs with cancer. Elevated BCM is hypothesised to place extra stress on bones weakened by cancer. Pathologic fracture following stereotactic body radiation therapy for canine appendicular osteosarcoma (OSA) frequently results in limb amputation or euthanasia. Additional tools are needed to better predict the risk of fracture development. Our objectives were to determine if any relationships could be identified between BCM and the occurrence of a pathologic fracture and/or survival time in dogs with naturally occurring OSA. Forty-seven dogs with a confirmed OSA and whole-body CT pre-SBRT were included. Several BCM were evaluated, including abdominal volume, visceral adipose tissue volume, whole-body volume, whole-body adipose tissue volume, normalised cross-sectional area of the epaxial muscles at the mid-body of the 13th thoracic vertebra, and attenuations of adipose tissue and epaxial muscles. No BCMs were correlated with survival time. The volume of the entire body (cm3) was significantly positively associated with development of a fracture. No other BCM were correlated with the development of a fracture. The volume of the abdomen (cm3) among our patient subset was positively correlated with the volume of the entire body, and the volume of visceral adipose tissue (cm3) was positively correlated with the total body volume of adipose tissue (cm3). Additional research is needed to verify whether these findings are replicable in larger sample sizes and in prospective settings.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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