黄斑上孔源性视网膜脱离行玻璃体切除前后视网膜前异常组织的多模态成像研究

IF 3.7 2区 医学 Q1 OPHTHALMOLOGY British Journal of Ophthalmology Pub Date : 2025-01-03 DOI:10.1136/bjo-2024-326442
Alberto Quarta, Lisa Toto, Maria Ludovica Ruggeri, Annamaria Porreca, Agbeanda Aharrh-Gnama, Lucio Zeppa, Lorenzo Motta, Matteo Gironi, Marta Di Nicola, Rodolfo Mastropasqua
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引用次数: 0

摘要

目的定量探讨黄斑上孔源性视网膜脱离(RRD)手术前后视网膜前异常组织(PAT)的变化。方法在本病例系列研究中,采用自定义平板的正面光学相干断层扫描图像对行玻璃体部切除术和SF6治疗视网膜黄斑病变的眼睛进行PAT检测。主要结局指标为基线时PAT面积、随访3个月、6个月及其相对变化。研究了PAT与浅毛细血管丛(SCP)中央凹无血管区(FAZ)、RRD区、视网膜撕裂区(RT)和内激光区之间的关系。结果36只黄斑眼RRD纳入分析。从基线到6个月,PAT显著增长(p<0.001)。基线PAT面积与RT面积相关(r=0.54, p=0.001)。PAT相对变化与FAZ SCP相对变化之间存在显著相关性。多变量回归模型显示,Endolaser面积(cm2)与PAT的相对变化有统计学意义(p=0.004)。结论:我们的研究发现,尽管视网膜再附着良好,但PAT在数月后会随着血管改变而增殖。激光面积对PAT生长有主要影响,但对最佳矫正视力没有影响。关于生长的病理生理机制的额外知识可以帮助了解哪种手术方法可能限制PAT的扩展和未来的继发性视网膜前膜。如有合理要求,可提供资料。支持本研究结果的数据和结果可根据通讯作者的合理要求提供。所有作者都证明他们符合当前ICMJE的作者标准。
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Preretinal abnormal tissue before and after pars plana vitrectomy in macula-on rhegmatogenous retinal detachment: a multimodal imaging study
Purpose To quantitatively explore preretinal abnormal tissue (PAT) in macula-on rhegmatogenous retinal detachment (RRD) before and after surgery. Methods In this case-series study, PAT was detected by en-face optical coherence tomography images with custom slabs in eyes that underwent pars plana vitrectomy and SF6 for macula-on RRD. Main outcome measures were PAT area at baseline, 3-month and 6-month follow-up, and its relative change. Associations between PAT and foveal avascular zone (FAZ) at superficial capillary plexus (SCP), RRD area, retinal tear (RT) area and endolaser area were investigated. Results 36 macula-on eyes RRD were included in the analysis. Significant PAT growth was registered from baseline until 6 months (p<0.001). Baseline PAT area correlated with RT area (r=0.54, p=0.001). Significant correlation between relative change in PAT and relative change in FAZ SCP was found. The multivariable regression model showed a statistically significant association between Endolaser area (cm2) and relative changes in PAT (p=0.004). Conclusions Our study found that despite good retinal reattachment, PAT proliferates over months with vascular changes. Endolaser area has a major influence on PAT growth, without impact on best-corrected visual acuity. Additional knowledge about pathophysiological mechanisms of growth could help understanding which surgical approach may limit PAT extension and future secondary epiretinal membrane. Data are available upon reasonable request. Data and results supporting this study’s findings are available upon reasonable request to the corresponding author. All authors attest that they meet the current ICMJE criteria for authorship.
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来源期刊
CiteScore
10.30
自引率
2.40%
发文量
213
审稿时长
3-6 weeks
期刊介绍: The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.
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