吗啡生物碱的不对称合成指南

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL Medicinal Chemistry Research Pub Date : 2024-11-21 DOI:10.1007/s00044-024-03350-9

Hui Zhao, Yunfei Cheng

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引用次数: 0

摘要

从罂粟中提取的一系列结构相关的天然化合物被称为吗啡生物碱。由于吗啡及其衍生物异常复杂的分子结构和特殊的生物活性，许多代的合成化学家都被吸引到吗啡及其衍生物的合成中。本文综述了吗啡生物碱不对称合成的最新进展，重点介绍了引入和控制手性的各种策略，这将加快吗啡inan商业化生产的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A guide for asymmetric synthesis of morphine alkaloids

A collection of structurally related natural compounds derived from Papaver somniferum, the opium poppy, are known as the morphine alkaloids. Many generations of synthetic chemists have been drawn to the synthesis of morphine and its derivatives owing to their extraordinarily complex molecular architecture and exceptional biological activity. This overview highlights recent advance in the asymmetric synthesis of morphine alkaloids, focusing on various strategies for introducing and controlling chirality, which will hasten the feasibility of commercial production of morphinan.

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.