{"title":"0.5s用力呼气量与成人全因死亡风险的关系","authors":"Fan Wu, Juncheng Liang, Ranxi Peng, Jie Ou, Shiyu Zhang, Leheng Tang, Qiaorui Zhou, Siman Liao, Yingtong Chen, Xiaozi Guo, Jingxian Chen, Qi Wan, Zihui Wang, Zhishan Deng, Yumin Zhou","doi":"10.1016/j.arbres.2024.12.006","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have proposed forced expiratory volume in 0.5s (FEV<sub>0.5</sub>) to determine health outcomes in infants and young children, but few studies exist in adults. This study aims to investigate the associations between FEV<sub>0.5</sub> and all-cause mortality in adults.</p><p><strong>Methods: </strong>Participants were enrolled from the National Health and Nutrition Examination Survey (NHANES) (1988-1994 [NHANES III] and 2007-2012 cycles). Participants aged≥20 years, not pregnant with qualifying prebronchodilator FEV<sub>0.5</sub> data, acceptable spirometry, complete body measurements, and follow-up data for mortality were included. The association between FEV<sub>0.5</sub> and all-cause mortality risk was evaluated by multivariable Cox regression. Restricted cubic spline analysis was used to evaluate the non-linear relationship between FEV<sub>0.5</sub> and all-cause mortality. Subgroup analyses were conducted with stratification by sex, age, body mass index, smoking status, and race.</p><p><strong>Results: </strong>Overall, 25,357 individuals were included, with a median follow-up of 308 months. The mean±standard deviation age was 46.1±7.2 years, and the mean prebronchodilator FEV<sub>0.5</sub> was 2412±699mL. A reduction in FEV<sub>0.5</sub> was associated with an increased all-cause mortality risk. A non-linear relationship was observed between FEV<sub>0.5</sub> and all-cause mortality risk. The results were maintained in subgroups analyses.</p><p><strong>Conclusion: </strong>FEV<sub>0.5</sub> was inversely associated with all-cause mortality risk in adults, indicating its potential for monitoring respiratory health.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Forced Expiratory Volume in 0.5s With All-Cause Mortality Risk in Adults.\",\"authors\":\"Fan Wu, Juncheng Liang, Ranxi Peng, Jie Ou, Shiyu Zhang, Leheng Tang, Qiaorui Zhou, Siman Liao, Yingtong Chen, Xiaozi Guo, Jingxian Chen, Qi Wan, Zihui Wang, Zhishan Deng, Yumin Zhou\",\"doi\":\"10.1016/j.arbres.2024.12.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Previous studies have proposed forced expiratory volume in 0.5s (FEV<sub>0.5</sub>) to determine health outcomes in infants and young children, but few studies exist in adults. This study aims to investigate the associations between FEV<sub>0.5</sub> and all-cause mortality in adults.</p><p><strong>Methods: </strong>Participants were enrolled from the National Health and Nutrition Examination Survey (NHANES) (1988-1994 [NHANES III] and 2007-2012 cycles). Participants aged≥20 years, not pregnant with qualifying prebronchodilator FEV<sub>0.5</sub> data, acceptable spirometry, complete body measurements, and follow-up data for mortality were included. The association between FEV<sub>0.5</sub> and all-cause mortality risk was evaluated by multivariable Cox regression. Restricted cubic spline analysis was used to evaluate the non-linear relationship between FEV<sub>0.5</sub> and all-cause mortality. Subgroup analyses were conducted with stratification by sex, age, body mass index, smoking status, and race.</p><p><strong>Results: </strong>Overall, 25,357 individuals were included, with a median follow-up of 308 months. The mean±standard deviation age was 46.1±7.2 years, and the mean prebronchodilator FEV<sub>0.5</sub> was 2412±699mL. A reduction in FEV<sub>0.5</sub> was associated with an increased all-cause mortality risk. A non-linear relationship was observed between FEV<sub>0.5</sub> and all-cause mortality risk. The results were maintained in subgroups analyses.</p><p><strong>Conclusion: </strong>FEV<sub>0.5</sub> was inversely associated with all-cause mortality risk in adults, indicating its potential for monitoring respiratory health.</p>\",\"PeriodicalId\":8339,\"journal\":{\"name\":\"Archivos De Bronconeumologia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos De Bronconeumologia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.arbres.2024.12.006\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos De Bronconeumologia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.arbres.2024.12.006","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Association of Forced Expiratory Volume in 0.5s With All-Cause Mortality Risk in Adults.
Introduction: Previous studies have proposed forced expiratory volume in 0.5s (FEV0.5) to determine health outcomes in infants and young children, but few studies exist in adults. This study aims to investigate the associations between FEV0.5 and all-cause mortality in adults.
Methods: Participants were enrolled from the National Health and Nutrition Examination Survey (NHANES) (1988-1994 [NHANES III] and 2007-2012 cycles). Participants aged≥20 years, not pregnant with qualifying prebronchodilator FEV0.5 data, acceptable spirometry, complete body measurements, and follow-up data for mortality were included. The association between FEV0.5 and all-cause mortality risk was evaluated by multivariable Cox regression. Restricted cubic spline analysis was used to evaluate the non-linear relationship between FEV0.5 and all-cause mortality. Subgroup analyses were conducted with stratification by sex, age, body mass index, smoking status, and race.
Results: Overall, 25,357 individuals were included, with a median follow-up of 308 months. The mean±standard deviation age was 46.1±7.2 years, and the mean prebronchodilator FEV0.5 was 2412±699mL. A reduction in FEV0.5 was associated with an increased all-cause mortality risk. A non-linear relationship was observed between FEV0.5 and all-cause mortality risk. The results were maintained in subgroups analyses.
Conclusion: FEV0.5 was inversely associated with all-cause mortality risk in adults, indicating its potential for monitoring respiratory health.
期刊介绍：
Archivos de Bronconeumologia is a scientific journal that specializes in publishing prospective original research articles focusing on various aspects of respiratory diseases, including epidemiology, pathophysiology, clinical practice, surgery, and basic investigation. Additionally, the journal features other types of articles such as reviews, editorials, special articles of interest to the society and editorial board, scientific letters, letters to the editor, and clinical images. Published monthly, the journal comprises 12 regular issues along with occasional supplements containing articles from different sections.
All manuscripts submitted to the journal undergo rigorous evaluation by the editors and are subjected to expert peer review. The editorial team, led by the Editor and/or an Associate Editor, manages the peer-review process. Archivos de Bronconeumologia is published monthly in English, facilitating broad dissemination of the latest research findings in the field.
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