CANAIRI:医疗保健领域转化人工智能试验合作组织

IF 58.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Medicine Pub Date : 2025-01-06 DOI:10.1038/s41591-024-03364-1
Melissa D. McCradden, Alex John London, Judy Wawira Gichoya, Mark Sendak, Lauren Erdman, Ian Stedman, Lauren Oakden-Rayner, Ismail Akrout, James A. Anderson, Lesley-Anne Farmer, Robert Greer, Anna Goldenberg, Yvonne Ho, Shalmali Joshi, Jennie Louise, Muhammad Mamdani, Mjaye L. Mazwi, Abdullahi Mohamud, Lyle J. Palmer, Antonios Peperidis, Stephen R. Pfohl, Mandy Rickard, Carolyn Semmler, Karandeep Singh, Devin Singh, Seyi Soremekun, Lana Tikhomirov, Anton H. van der Vegt, Karin Verspoor, Xiaoxuan Liu
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引用次数: 0

摘要

过去几年,人工智能(AI)临床翻译的权威、可信指导主要围绕两个方面形成:负责任的模型开发和验证;以及前瞻性临床试验。最初的工作重点是建立一个好的模型,这通常意味着一个模型表现良好,解决一个重要的临床任务,训练正确的数据来解决这个任务,并可以用于一些有意义的目标。然后应该根据一组看不见的用例对模型进行评估,以确保它可以推广到测试集之外,并且可以在外部进行潜在的测试。进一步的实践正在围绕持续监测来检测模型漂移和性能变化。总的来说,这些实践被描述为负责任的机器学习。然而,在计算机环境和临床环境之间的区别是实质性的,这突出了临床评估的必要性。2020年,发布了SPIRIT-AI和CONSORT-AI报告指南,为评估AI模型影响的前瞻性、介入性临床试验建立了最低报告标准2,3。此后不久,decision -AI指南发布,以解决人工智能工具的首次人体可行性试验4。监管框架强调临床证据的重要性,但确切地说,批准临床人工智能应用需要什么样的证据和程度是一个不确定的问题5。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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来源期刊
Nature Medicine
Nature Medicine 医学-生化与分子生物学
CiteScore
100.90
自引率
0.70%
发文量
525
审稿时长
1 months
期刊介绍: Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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