18F-FAZA， 18F-FDG和123I-IMP成像揭示急性MOGAD的缺氧和代谢

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical Nuclear Medicine Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI:10.1097/RLU.0000000000005671

Kota Yokoyama, Junichi Tsuchiya, Hiroya Kuwahara, Motoki Inaji, Ukihide Tateishi

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摘要

摘要：我们报告第一例髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD），使用18F-FAZA PET/CT进行缺氧成像评估。一名20多岁的健康女性因癫痫、头痛和呕吐来到我们医院。MRI和CT扫描显示了广泛的鉴别诊断，从肿瘤病变，如恶性淋巴瘤，到炎症性疾病，如血管炎，使她的病例难以诊断。髓鞘少突胶质细胞糖蛋白抗体阳性证实MOGAD，类固醇治疗后病情好转。本病例的18F-FAZA PET/CT表现可能有助于了解MOGAD的发病机制。

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18 F-FAZA, 18 F-FDG, and 123 I-IMP Imaging Reveal Hypoxia and Metabolism in Acute MOGAD.

Abstract: We report the first case of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) evaluated with hypoxic imaging using 18 F-FAZA PET/CT. A healthy woman in her 20s presented to our hospital with seizures, headaches, and vomiting. MRI and CT scans suggested a wide range of differential diagnoses, from neoplastic lesions, such as malignant lymphoma, to inflammatory diseases, such as vasculitis, making her case challenging to diagnose. MOGAD was confirmed by positive myelin oligodendrocyte glycoprotein antibodies, and her condition improved with steroid therapy. The 18 F-FAZA PET/CT findings in this case may aid in understanding the pathogenesis of MOGAD.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.