青少年娱乐性氯胺酮使用者的精神病样经验:个案研究。

IF 2.1 4区 医学 Q2 PSYCHOLOGY, CLINICAL Journal of psychoactive drugs Pub Date : 2025-01-08 DOI:10.1080/02791072.2025.2449909
Valerio Ricci, Domenico De Berardis, Sheikh Shoib, Giovanni Martinotti, Giuseppe Maina
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引用次数: 0

摘要

本研究探讨了与青年人娱乐性氯胺酮使用相关的精神病样体验(ple)。氯胺酮最初是作为麻醉剂引入的,现在由于其解离作用被广泛用于娱乐,这引起了人们对其对精神健康影响的担忧。10名年龄在18-24岁之间的参与者,每周多次使用氯胺酮娱乐,使用社区心理体验评估(CAPE-42)进行评估。结果显示氯胺酮的使用频率与ple之间存在显著的正相关,而THC、MDMA和酒精等其他物质对ple的影响不显著。这些发现证实了氯胺酮通过拮抗NMDA受体诱发类似精神分裂症的精神病症状的潜力。该研究强调需要采取预防措施和有针对性的干预措施,以解决频繁使用氯胺酮的心理健康风险,特别是在年轻人中。然而,样本量小和依赖自我报告数据等局限性表明,需要进一步研究以确定因果关系并检查长期影响。总的来说,本研究强调了娱乐性氯胺酮使用与PLEs增加之间的显著关联,强调了早期发现和干预策略的重要性。
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Psychotic-Like Experiences in Young Recreational Users of Ketamine: A Case Study.

This study explores the psychotic-like experiences (PLEs) associated with recreational ketamine use among young adults. Ketamine, initially introduced as an anesthetic, is now widely used recreationally for its dissociative effects, raising concerns about its impact on mental health. Ten participants aged 18-24, who used ketamine recreationally multiple times a week, were assessed using the Community Assessment of Psychic Experiences (CAPE-42). Results showed a significant positive correlation between the frequency of ketamine use and PLEs, with no significant impact from other substances like THC, MDMA, and alcohol. These findings confirm ketamine's potential to induce psychotic-like symptoms by antagonizing NMDA receptors, similar to schizophrenia. The study underscores the need for preventive measures and targeted interventions to address the mental health risks of frequent ketamine use, particularly among young adults. However, limitations such as the small sample size and reliance on self-reported data suggest that further research is needed to establish causality and examine long-term effects. Overall, this study highlights the significant association between recreational ketamine use and increased PLEs, emphasizing the importance of early detection and intervention strategies.

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来源期刊
CiteScore
5.30
自引率
7.10%
发文量
62
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