{"title":"从泽泻中分离的生物碱和木脂素通过调节细胞凋亡信号通路表现出抗肺纤维化活性。","authors":"Deng-Hui Zhu , Jing-Ke Zhang , Peng-Li Guo , Si-Qi Tao , Meng-Nan Zeng , Xiao-Ke Zheng , Wei-Sheng Feng","doi":"10.1016/j.phytochem.2025.114382","DOIUrl":null,"url":null,"abstract":"<div><div>From the tuber of <em>Alisma orientale</em> (Sam.) Juzep. (<em>Alismataceae</em>), twenty-four compounds were isolated, including six (<strong>1</strong>, <strong>2</strong>, <strong>3</strong>, <strong>10</strong>, <strong>14</strong>, and <strong>17</strong>) that were not yet characterized. Spectroscopic investigations (IR, UV, HRESIMS, and NMR) were used to clarify their structures, and the ECD spectra of two compounds (<strong>8</strong> and <strong>9</strong>) were interpreted to identify their absolute configurations. Through an apoptotic signaling pathway, compounds <strong>7</strong>, <strong>15</strong>, <strong>17</strong>, and <strong>19</strong> decreased the level of apoptosis in lung epithelial cells, indicating that they may have potential anti-pulmonary fibrosis (anti-PF) activity.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"233 ","pages":"Article 114382"},"PeriodicalIF":3.2000,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Alkaloids and lignans isolated from Alisma orientale exhibit anti-pulmonary fibrosis activities by modulating an apoptotic signaling pathway\",\"authors\":\"Deng-Hui Zhu , Jing-Ke Zhang , Peng-Li Guo , Si-Qi Tao , Meng-Nan Zeng , Xiao-Ke Zheng , Wei-Sheng Feng\",\"doi\":\"10.1016/j.phytochem.2025.114382\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>From the tuber of <em>Alisma orientale</em> (Sam.) Juzep. (<em>Alismataceae</em>), twenty-four compounds were isolated, including six (<strong>1</strong>, <strong>2</strong>, <strong>3</strong>, <strong>10</strong>, <strong>14</strong>, and <strong>17</strong>) that were not yet characterized. Spectroscopic investigations (IR, UV, HRESIMS, and NMR) were used to clarify their structures, and the ECD spectra of two compounds (<strong>8</strong> and <strong>9</strong>) were interpreted to identify their absolute configurations. Through an apoptotic signaling pathway, compounds <strong>7</strong>, <strong>15</strong>, <strong>17</strong>, and <strong>19</strong> decreased the level of apoptosis in lung epithelial cells, indicating that they may have potential anti-pulmonary fibrosis (anti-PF) activity.</div></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":\"233 \",\"pages\":\"Article 114382\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-01-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942225000056\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942225000056","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Alkaloids and lignans isolated from Alisma orientale exhibit anti-pulmonary fibrosis activities by modulating an apoptotic signaling pathway
From the tuber of Alisma orientale (Sam.) Juzep. (Alismataceae), twenty-four compounds were isolated, including six (1, 2, 3, 10, 14, and 17) that were not yet characterized. Spectroscopic investigations (IR, UV, HRESIMS, and NMR) were used to clarify their structures, and the ECD spectra of two compounds (8 and 9) were interpreted to identify their absolute configurations. Through an apoptotic signaling pathway, compounds 7, 15, 17, and 19 decreased the level of apoptosis in lung epithelial cells, indicating that they may have potential anti-pulmonary fibrosis (anti-PF) activity.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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