德国系统性红斑狼疮的真实世界患病率、发病率和管理：回顾性索赔数据分析。

IF 2.9 3区医学 Q2 RHEUMATOLOGY Rheumatology and Therapy Pub Date : 2025-01-08 DOI:10.1007/s40744-024-00735-5

Tobias Alexander, Philipp Sewerin, Anja Strangfeld, Marcus Schulte, Julia Borchert, Tarcyane Barata Garcia, Eva Schrom

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引用次数: 0

摘要

本研究评估了德国系统性红斑狼疮（SLE）的患病率和发病率，并探索了治疗顺序(SOT；临床用药顺序)。方法:这项回顾性、观察性、纵向队列研究使用来自WIG2 GmbH科学研究所卫生经济和卫生系统研究数据库（2011年1月- 2019年12月）的德国索赔数据，外推到法定健康保险（SHI）参保人群，评估流行病学分析组的患病率和发病率以及事件队列（亚组≥18岁，发生疾病，在索引日期后随访≥24个月）的SLE治疗模式。分析是描述性的。结果：基于流行病学分析（N = 3017）， SHI人群SLE年患病率从2012年的40.47 / 10万逐渐上升至2019年的59.87 / 10万。相比之下，SLE的年发病率相对稳定，从2012年的8.83到2019年的8.86。在事件队列（n = 941）中，基于SOT分析（n = 681）， bbb60天的治疗间隔很常见：SOT1、SOT2和SOT3分别为67.1%、51.2%和54.9%。皮质类固醇是SOT1中最常见的单药治疗（31.0% vs 0% SOT2/SOT3）；30.0% -70.0%的患者接受了皮质类固醇联合治疗。在每种SOT中，50%以上的患者接受了抗疟治疗（联合或单一治疗）。生物疾病缓解药物的使用较低，从SOT1的0.4%到SOT3的9.7%不等。结论：我们的数据显示，德国SLE患病率增加，发病率稳定，这表明受影响患者的生存率提高。然而，次优治疗模式，包括有限使用生物制剂，反映了SLE患者对优化和个性化治疗的高度未满足需求。

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Real-World Prevalence, Incidence and Management of Systemic Lupus Erythematosus in Germany: A Retrospective Claims Data Analysis.

Introduction: This study evaluated the prevalence and incidence of systemic lupus erythematosus (SLE) in Germany and explored real-world data on sequence of therapy (SOT; sequence of drugs as prescribed in clinical practice).

Methods: This retrospective, observational, longitudinal cohort study using German claims data from the WIG2 GmbH Scientific Institute for Health Economics and Health System Research database (January 2011-December 2019), extrapolated to the statutory health insurance (SHI)-insured population, evaluated prevalence and incidence in an epidemiological analysis group and SLE treatment patterns in an incident cohort (subgroup ≥ 18 years of age with incident disease and ≥ 24-month follow-up post index date). Analyses were descriptive.

Results: Based on the epidemiological analysis (N = 3017), annual SLE prevalence per 100,000 gradually increased from 40.47 in 2012 to 59.87 in 2019 in the SHI population. In contrast, annual SLE incidence was relatively stable, ranging from 8.83 in 2012 to 8.86 in 2019. In the incident cohort (n = 941), based on SOT analysis (n = 681), treatment gaps of > 60 days were common: 67.1%, 51.2% and 54.9% in SOT1, SOT2 and SOT3, respectively. Corticosteroids were the most frequent monotherapy in SOT1 (31.0% vs 0% in SOT2/SOT3); 30.0-70.0% of patients received a corticosteroid combination therapy across SOTs. Over 50% of patients in each SOT received an antimalarial therapy (combination or monotherapies). The use of biologic disease-modifying drugs was low, ranging from 0.4% in SOT1 to 9.7% in SOT3.

Conclusions: Our data demonstrate an increased prevalence of SLE with stable incidence in Germany, suggesting improved survival of affected patients. Nevertheless, suboptimal treatment patterns, including limited use of biologics, reflect a high unmet need for optimised and personalised therapies in patients with SLE.

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来源期刊

Rheumatology and Therapy RHEUMATOLOGY-

CiteScore

6.00

自引率

5.30%

发文量

审稿时长

6 weeks

期刊介绍： Aims and Scope Rheumatology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of rheumatologic therapies. Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. Areas of focus include, but are not limited to, rheumatoid arthritis, gout, gouty arthritis, psoriatic arthritis, osteoarthritis, juvenile idiopathic/rheumatoid arthritis, systemic lupus erythematosus, axial spondyloarthritis, Pompe’s disease, inflammatory joint conditions, musculoskeletal conditions, systemic sclerosis, and fibromyalgia. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial protocols, communications and letters. 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