Gli1+间充质干细胞在颅面发育和疾病治疗中的作用。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of oral rehabilitation Pub Date : 2025-01-10 DOI:10.1111/joor.13917

Wen Li, Han Jiang, Longshuang Hu, Tianjiao Shen, Qianming Chen

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引用次数: 0

摘要

目的：综述Gli1+（胶质瘤相关癌基因同源物1）间充质干细胞在颅面生长发育和组织修复中的作用及其在某些疾病治疗中的应用。设计：本叙述性综述在PubMed和Web of Science中使用相关关键词进行检索，包括手工检索期刊文章的参考文献列表。结果：Gli1+间充质干细胞在颅骨、牙齿、牙周组织和下颌髁的生长发育中起重要作用。可应用于牙髓及牙周病、颞下颌关节骨性关节炎等疾病的治疗。结论：Gli1+间充质干细胞在颅面组织发育和修复中起着至关重要的作用。

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The Role of Gli1⁺ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment.

Objective: This review summarises the role of Gli1⁺ (Glioma-associated oncogene homologue 1) mesenchymal stem cells in craniofacial growth and development or tissue repair, and their application in the treatment of some diseases.

Design: The search for this narrative review was conducted in PubMed and Web of Science using relevant keywords, including checking reference lists of journal articles by hand searching.

Results: Gli1⁺ mesenchymal stem cells play an important role in the growth and development of the skull, tooth, periodontium and mandibular condyle. They can be applied to the treatment of pulp and periodontal diseases, temporomandibular joint osteoarthritis and other diseases.

Conclusions: Gli1⁺ mesenchymal stem cells are crucial for the development and repair of craniofacial tissue.

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来源期刊

Journal of oral rehabilitation 医学-牙科与口腔外科

CiteScore

5.60

自引率

10.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： Journal of Oral Rehabilitation aims to be the most prestigious journal of dental research within all aspects of oral rehabilitation and applied oral physiology. It covers all diagnostic and clinical management aspects necessary to re-establish a subjective and objective harmonious oral function. Oral rehabilitation may become necessary as a result of developmental or acquired disturbances in the orofacial region, orofacial traumas, or a variety of dental and oral diseases (primarily dental caries and periodontal diseases) and orofacial pain conditions. As such, oral rehabilitation in the twenty-first century is a matter of skilful diagnosis and minimal, appropriate intervention, the nature of which is intimately linked to a profound knowledge of oral physiology, oral biology, and dental and oral pathology. The scientific content of the journal therefore strives to reflect the best of evidence-based clinical dentistry. Modern clinical management should be based on solid scientific evidence gathered about diagnostic procedures and the properties and efficacy of the chosen intervention (e.g. material science, biological, toxicological, pharmacological or psychological aspects). The content of the journal also reflects documentation of the possible side-effects of rehabilitation, and includes prognostic perspectives of the treatment modalities chosen.