Boyang Liu , Linjing Zhu , Linfang Bian , Dezhong Wen , Xueling Cui
{"title":"激活素A对肿瘤双重作用的研究进展。","authors":"Boyang Liu , Linjing Zhu , Linfang Bian , Dezhong Wen , Xueling Cui","doi":"10.1016/j.bbrc.2025.151301","DOIUrl":null,"url":null,"abstract":"<div><div>Activin A, a gonadal protein, not only stimulates the pituitary to secrete follicle-stimulating hormone (FSH) but also plays a crucial role in regulating various cell behaviors, such as cell proliferation, differentiation, apoptosis, migration, and invasion. Studies have shown an association between activin A expression and tumor progression, highlighting its dual role in cancer. Similar to transforming growth factor-beta (TGF-β), activin A can have both pro-tumor and anti-tumor effects, for instance, it inhibits the migration of lung adenocarcinoma cells, while promotes the migration of triple-negative breast cancer cells. Therefore, activin A exerts context-dependent effects on different tumor cells. This review explores the biological functions of activin A in tumor progression and treatment, focusing on its influence on tumor cell proliferation, apoptosis, and metastasis. The aim is to offer insights and potential directions for future clinical cancer treatments.</div></div>","PeriodicalId":8779,"journal":{"name":"Biochemical and biophysical research communications","volume":"747 ","pages":"Article 151301"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recent advances in the dual effects of activin A on tumors\",\"authors\":\"Boyang Liu , Linjing Zhu , Linfang Bian , Dezhong Wen , Xueling Cui\",\"doi\":\"10.1016/j.bbrc.2025.151301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Activin A, a gonadal protein, not only stimulates the pituitary to secrete follicle-stimulating hormone (FSH) but also plays a crucial role in regulating various cell behaviors, such as cell proliferation, differentiation, apoptosis, migration, and invasion. Studies have shown an association between activin A expression and tumor progression, highlighting its dual role in cancer. Similar to transforming growth factor-beta (TGF-β), activin A can have both pro-tumor and anti-tumor effects, for instance, it inhibits the migration of lung adenocarcinoma cells, while promotes the migration of triple-negative breast cancer cells. Therefore, activin A exerts context-dependent effects on different tumor cells. This review explores the biological functions of activin A in tumor progression and treatment, focusing on its influence on tumor cell proliferation, apoptosis, and metastasis. The aim is to offer insights and potential directions for future clinical cancer treatments.</div></div>\",\"PeriodicalId\":8779,\"journal\":{\"name\":\"Biochemical and biophysical research communications\",\"volume\":\"747 \",\"pages\":\"Article 151301\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemical and biophysical research communications\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0006291X25000154\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemical and biophysical research communications","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0006291X25000154","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Recent advances in the dual effects of activin A on tumors
Activin A, a gonadal protein, not only stimulates the pituitary to secrete follicle-stimulating hormone (FSH) but also plays a crucial role in regulating various cell behaviors, such as cell proliferation, differentiation, apoptosis, migration, and invasion. Studies have shown an association between activin A expression and tumor progression, highlighting its dual role in cancer. Similar to transforming growth factor-beta (TGF-β), activin A can have both pro-tumor and anti-tumor effects, for instance, it inhibits the migration of lung adenocarcinoma cells, while promotes the migration of triple-negative breast cancer cells. Therefore, activin A exerts context-dependent effects on different tumor cells. This review explores the biological functions of activin A in tumor progression and treatment, focusing on its influence on tumor cell proliferation, apoptosis, and metastasis. The aim is to offer insights and potential directions for future clinical cancer treatments.
期刊介绍：
Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology
; molecular biology; neurobiology; plant biology and proteomics
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