Mohammad Nikoohemmat, Amirhossein Ramezani Ahmadi, Ali Valizadeh, Seyed Mohammadmisagh Moteshakereh, Reza Yari-Boroujeni, Zahra Seifi, Majid Valizadeh, Behnaz Abiri
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Inclusion criteria involved original observational studies, with cross-sectional or longitudinal designs, reporting body composition parameters and vascular health measures. The Newcastle-Ottawa Scale (NOS) assessed study quality. Statistical analyses utilized Stata 17.0, employing random-effects meta-analysis, sensitivity analysis, and evaluation of publication bias.</p><p><strong>Results: </strong>Fifteen observational studies (n = 21,215) met the inclusion criteria. Pooled analyses revealed a positive association between fat-free mass (FFM) and carotid intima-media thickness (IMT) (effect size [ES]: 1.79, 95% CI 1.68-1.91), highlighting a relationship with arterial structure. Similarly, body fat percentage (BFP) was positively associated with PWV (ES: 1.45, 95% CI 1.15-1.82), and FFM showed a positive association with CAVI (ES: 1.46, 95% CI 0.78-2.71), both measures of arterial stiffness. Subgroup analyses revealed a non-significant association between appendicular skeletal muscle (ASM) and IMT (ES: 1.01, 95% CI 0.76-1.35).</p><p><strong>Conclusion: </strong>This meta-analysis highlights the complex relationship between body composition and vascular health. 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引用次数: 0
摘要
目的：本系统综述探讨了身体组成（特别是骨骼肌质量）与血管健康指数（包括动脉刚度-脉搏波速度（PWV）和心踝血管指数（CAVI））以及动脉结构（特别是颈动脉内膜-中膜厚度（cIMT））之间的复杂关系。方法：广泛的文献检索，包括PubMed， Scopus， EMBASE， Web of Science和谷歌Scholar，进行到2024年1月。纳入标准包括原始观察性研究，采用横断面或纵向设计，报告身体组成参数和血管健康指标。纽卡斯尔-渥太华量表（NOS）评估研究质量。统计分析采用Stata 17.0，采用随机效应荟萃分析、敏感性分析和发表偏倚评价。结果：15项观察性研究（n = 21,215）符合纳入标准。合并分析显示，无脂质量（FFM）与颈动脉内膜-中膜厚度（IMT）呈正相关（效应值[ES]: 1.79, 95% CI 1.68-1.91），强调了与动脉结构的关系。同样，体脂率（BFP）与PWV呈正相关（ES: 1.45, 95% CI 1.15-1.82）， FFM与CAVI呈正相关（ES: 1.46, 95% CI 0.78-2.71），两者都是动脉硬度的测量指标。亚组分析显示，阑尾骨骼肌（ASM）与IMT之间无显著相关性（ES: 1.01, 95% CI 0.76-1.35）。结论：这项荟萃分析强调了身体成分与血管健康之间的复杂关系。亚组分析表明，需要进一步研究具体的身体成分指数及其临床意义。证据水平：III从设计良好的队列和横断面研究中获得的证据。
Association between body composition indices and vascular health: a systematic review and meta-analysis.
Objective: This systematic review explores the intricate relationship between body composition, with a specific focus on skeletal muscle mass, and vascular health indices, including measures of arterial stiffness-pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI)-as well as arterial structure, specifically carotid artery intima-media thickness (cIMT).
Methods: An extensive literature search, encompassing PubMed, Scopus, EMBASE, Web of Science, and Google Scholar, was conducted until January 2024. Inclusion criteria involved original observational studies, with cross-sectional or longitudinal designs, reporting body composition parameters and vascular health measures. The Newcastle-Ottawa Scale (NOS) assessed study quality. Statistical analyses utilized Stata 17.0, employing random-effects meta-analysis, sensitivity analysis, and evaluation of publication bias.
Results: Fifteen observational studies (n = 21,215) met the inclusion criteria. Pooled analyses revealed a positive association between fat-free mass (FFM) and carotid intima-media thickness (IMT) (effect size [ES]: 1.79, 95% CI 1.68-1.91), highlighting a relationship with arterial structure. Similarly, body fat percentage (BFP) was positively associated with PWV (ES: 1.45, 95% CI 1.15-1.82), and FFM showed a positive association with CAVI (ES: 1.46, 95% CI 0.78-2.71), both measures of arterial stiffness. Subgroup analyses revealed a non-significant association between appendicular skeletal muscle (ASM) and IMT (ES: 1.01, 95% CI 0.76-1.35).
Conclusion: This meta-analysis highlights the complex relationship between body composition and vascular health. Subgroup analyses suggest the need for further research into specific body composition indices and their clinical implications.
Level of evidence: III evidence obtained from well-designed cohort and cross-sectional studies.
期刊介绍：
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a scientific journal whose main purpose is to create an international forum devoted to the several sectors of eating disorders and obesity and the significant relations between them. The journal publishes basic research, clinical and theoretical articles on eating disorders and weight-related problems: anorexia nervosa, bulimia nervosa, subthreshold eating disorders, obesity, atypical patterns of eating behaviour and body weight regulation in clinical and non-clinical populations.
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