眼肿瘤质子治疗中聚合物幻影的蒙特卡罗模拟

IF 2.8 3区 物理与天体物理 Q2 PHYSICS, MULTIDISCIPLINARY The European Physical Journal Plus Pub Date : 2025-01-15 DOI:10.1140/epjp/s13360-024-05944-z
Engin Aşlar, Fatih Ekinci
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引用次数: 0

摘要

治疗眼肿瘤的传统方法,如手术和放射疗法,可能会对周围的健康组织造成损害,并产生不必要的副作用。近年来,质子治疗已成为治疗眼部肿瘤的重要替代方法。质子治疗利用质子粒子靶向癌细胞,同时尽量减少对周围健康组织的损害。与其他放射治疗技术不同,质子治疗使用布拉格峰,它允许质子集中在组织内的特定深度。质子治疗可以向肿瘤区域提供高剂量的辐射,同时保护附近的健康组织。此外,质子治疗比其他治疗方法具有更有利的副作用。本研究的重点是对眼睛和眼幻影进行模拟,以检查质子治疗对眼睛组织的影响。模拟分析了物理效应,如电离、反冲和质子束的横向散射,使用布拉格曲线、反冲分析和原子水平的相互作用。结果表明,随着质子束能级的增加,质子束在眼组织中的范围和能量转移也增加。这些发现强调了质子治疗眼肿瘤的潜在有效性。聚合物眼幻影可以作为质子治疗模拟的可靠工具来优化治疗计划。这项研究强调了质子治疗模拟的重要性,并展示了各种聚合物材料的成功使用。未来的研究还可以考察重粒子对不同高分子材料的影响,以全面评估质子束在生物医学应用中的影响。
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Monte Carlo simulation of polymer phantoms in proton therapy for eye tumor treatment

Traditional methods for treating eye tumors, such as surgery and radiation therapy, can cause damage to surrounding healthy tissues and unwanted side effects. In recent years, proton therapy has emerged as a significant alternative for the treatment of eye tumors. Proton therapy targets cancer cells using proton particles while minimizing damage to the surrounding healthy tissues. Unlike other radiation therapy techniques, proton therapy uses the Bragg peak, which allows protons to concentrate on a specific depth within the tissue. Proton therapy can deliver a high dose of radiation to the tumor area while protecting nearby healthy tissues. Additionally, proton therapy has a more favorable side effect profile than other treatment methods. This study focuses on simulations conducted on eyes and eye phantoms to examine the effects of proton therapy on eye tissues. The simulations analyzed physical effects such as ionization, recoils, and lateral straggle of proton beams using Bragg curves, recoil analyses, and atomic-level interactions. Results indicate that as the energy levels of proton beams increase, the range and energy transfer in eye tissues also increase. These findings emphasize the potential effectiveness of proton therapy for treating eye tumors. Polymer eye phantoms can serve as reliable tools in proton therapy simulations to optimize treatment planning. This study highlights the importance of proton therapy simulations and demonstrates the successful use of various polymer materials. Future studies may also examine the effects of heavy particles in addition to different polymer materials to comprehensively evaluate the impact of proton beams in biomedical applications.

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来源期刊
The European Physical Journal Plus
The European Physical Journal Plus PHYSICS, MULTIDISCIPLINARY-
CiteScore
5.40
自引率
8.80%
发文量
1150
审稿时长
4-8 weeks
期刊介绍: The aims of this peer-reviewed online journal are to distribute and archive all relevant material required to document, assess, validate and reconstruct in detail the body of knowledge in the physical and related sciences. The scope of EPJ Plus encompasses a broad landscape of fields and disciplines in the physical and related sciences - such as covered by the topical EPJ journals and with the explicit addition of geophysics, astrophysics, general relativity and cosmology, mathematical and quantum physics, classical and fluid mechanics, accelerator and medical physics, as well as physics techniques applied to any other topics, including energy, environment and cultural heritage.
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