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IF 10.1 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environmental Health Perspectives Pub Date : 2025-01-01 Epub Date: 2025-01-14 DOI:10.1289/EHP14493

Kemi Ogunsina, Katie M O'Brien, Alexandra J White, Che-Jung Chang, Symielle A Gaston, Chandra L Jackson, Dale P Sandler

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引用次数: 0

摘要

背景：子宫肌瘤对黑人妇女的影响尤为严重，而接触来自理发器或直发器（"直发器"）的化学物质可能会导致子宫肌瘤的发生：我们研究了直发器的使用与年轻发病型子宫肌瘤（36 岁前确诊）以及偶发性子宫肌瘤（36-60 岁确诊）之间的关联，重点关注黑人女性。我们还研究了作为配方变化替代物的不同出生队列之间的关联差异：我们分析了姐妹研究（Sister Study）中 4,162 名黑人女性的数据，该研究是一项针对 35-74 岁女性的前瞻性队列研究（2003-2009 年注册）。我们使用逻辑回归估算了10-13岁时使用矫直机与自我报告的年轻子宫肌瘤之间的相关几率比（ORs）。我们使用 Cox 回归评估了 779 名绝经前黑人妇女使用矫直机（10-13 岁和入组前 12 个月）与发病子宫肌瘤的危险比 (HRs)。对 40782 名非西班牙裔白人妇女进行了类似分析：结果：超过 70% 的黑人妇女使用直发器。与不使用直发器相比，10-13 岁时使用任何直发器[OR=1.15；95% 置信区间 (CI)：0.96, 1.36]和频繁使用直发器（OR=1.18；95% CI：0.99, 1.42）与年轻时发病的子宫肌瘤有关。这种关联在1928年至1945年（OR=1.78；95% CI：1.15，2.74）和1965年至1974年（OR=1.64；95% CI：0.82，3.29）出生的人群中最为明显。36岁至60岁的子宫肌瘤发病率与10-13岁使用直发器[危险比（HR）=1.14；95% CI：0.81，1.63]和入组前12个月使用直发器（HR=1.32；95% CI：0.88，2.00）略有关联。在非西班牙裔白种女性中，尽管拉直器的使用率较低（≤5%），但10-13岁时使用拉直器同样与年轻时发病的子宫肌瘤有关（OR=1.23；95% CI：1.03，1.47）。敏感性分析表明，子宫肌瘤分类错误可能会造成偏差，如果无子宫妇女或来自教育程度较低家庭的妇女报告其子宫肌瘤状况的准确性较低，则可能会高估其影响：讨论：直发器的使用可能与子宫肌瘤风险呈正相关。https://doi.org/10.1289/EHP14493。

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Hair Straightener Use in Relation to Prevalent and Incident Fibroids in the Sister Study with a Focus on Black Women.

Background: Uterine fibroids disproportionately affect Black women, and exposure to chemicals from hair relaxers or straighteners ("straighteners") may contribute to fibroid development.

Objectives: We examined the association between straightener use and prevalent young-onset uterine fibroids (diagnosed before age 36 y), as well as incident fibroids (diagnosed age 36-60 y), with a focus on Black women. We also examined differences in associations across birth cohorts as proxies for formulation changes.

Methods: Data from 4,162 Black women in the Sister Study, a prospective cohort of women 35-74 y of age (enrolled 2003-2009), were analyzed. We used logistic regression to estimate odds ratios (ORs) for the association of straightener use at 10-13 y of age and self-reported young-onset fibroids. We used Cox regression to assess hazard ratios (HRs) for straightener use (age 10-13 y and in 12 months before enrollment) and incident fibroids among 779 premenopausal Black women. Similar analyses were conducted in 40,782 non-Hispanic White women.

Results: Over 70% of Black women used straighteners. In comparison with no use, any [ $OR = 1.15$ ; 95% confidence interval (CI): 0.96, 1.36] and frequent use ( $OR = 1.18$ ; 95% CI: 0.99, 1.42) of straighteners at 10-13 y of age were associated with young-onset fibroids. This association was most apparent among those born between 1928 and 1945 ( $OR = 1.78$ ; 95% CI: 1.15, 2.74) and 1965-1974 ( $OR = 1.64$ ; 95% CI: 0.82, 3.29). Fibroid incidence from 36 to 60 y of age was modestly associated with use of straighteners at 10-13 y of age [hazard ratio $(HR) = 1.14$ ; 95% CI: 0.81, 1.63] and in the 12 months prior to enrollment ( $HR = 1.32$ ; 95% CI: 0.88, 2.00). Among non-Hispanic White women, straightener use at 10-13 y of age was similarly associated with young-onset fibroids ( $OR = 1.23$ ; 95% CI: 1.03, 1.47) despite lower use ( $\leq 5 %$ ) of straighteners. Sensitivity analyses indicated a potential for bias due to fibroid misclassification, with an overestimation of the effect likely if nulliparous women or women from households with lower education reported their fibroid status less accurately.

Discussion: Hair straightener use may be positively associated with fibroid risk. https://doi.org/10.1289/EHP14493.

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来源期刊

Environmental Health Perspectives 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

14.40

自引率

2.90%

发文量

388

审稿时长

6 months

期刊介绍： Environmental Health Perspectives (EHP) is a monthly peer-reviewed journal supported by the National Institute of Environmental Health Sciences, part of the National Institutes of Health under the U.S. Department of Health and Human Services. Its mission is to facilitate discussions on the connections between the environment and human health by publishing top-notch research and news. EHP ranks third in Public, Environmental, and Occupational Health, fourth in Toxicology, and fifth in Environmental Sciences.