{"title":"中药治疗肝癌：网络药理学研究。","authors":"Shihao Zheng, Yixiao Gu, Wenying Qi, Wei Wang, Xiaoke Li, Xiaobin Zao, Size Li, Shaoyu Liu, Tianyu Xue, Yongan Ye, Aimin Liu","doi":"10.2174/0115680266336478241118065659","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>As one of the common malignant tumors nowadays, liver cancer has more risk factors for its development and is characterized by a high recurrence rate, high mortality rate, and poor prognosis, which poses a great threat to people's health. The specific efficacy of traditional Chinese medicine is based on clinical practice, which is a high degree of generalization of the characteristics and scope of the clinical effects of prescription medicines and a special form of expression of the medical effects of the human body within the scope of traditional Chinese medicine. Because of its multi-ingredient, multi-target, and multi-pathway characteristics, it has a great advantage in the treatment of liver cancer. Still, at present, its specific molecular mechanism of action has not yet been clarified.</p><p><strong>Aim: </strong>This study reviews the current status and characteristics of network pharmacology research in the treatment of liver cancer, aiming to provide new ideas and methods for traditional Chinese medicine treatment of the disease.</p><p><strong>Methods: </strong>This study was searched on the Web of Science and PubMed using keywords, such as \"traditional Chinese medicine\", \"liver cancer,\" and \"network pharmacology.\" The citation dates of the literature cited in this review are from 2000 to 2024.</p><p><strong>Results: </strong>The discovery of the key molecular mechanisms of traditional Chinese medicine in the treatment of liver cancer through the network pharmacology approach and the in-depth study of the related signaling pathways are conducive to a more in-depth exploration of traditional Chinese medicine.</p><p><strong>Conclusion: </strong>Network pharmacology research plays a key role in the treatment and prevention of liver cancer and deserves deeper exploration in the future.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Traditional Chinese Medicine for Liver Cancer Treatment: Network Pharmacology Research.\",\"authors\":\"Shihao Zheng, Yixiao Gu, Wenying Qi, Wei Wang, Xiaoke Li, Xiaobin Zao, Size Li, Shaoyu Liu, Tianyu Xue, Yongan Ye, Aimin Liu\",\"doi\":\"10.2174/0115680266336478241118065659\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>As one of the common malignant tumors nowadays, liver cancer has more risk factors for its development and is characterized by a high recurrence rate, high mortality rate, and poor prognosis, which poses a great threat to people's health. The specific efficacy of traditional Chinese medicine is based on clinical practice, which is a high degree of generalization of the characteristics and scope of the clinical effects of prescription medicines and a special form of expression of the medical effects of the human body within the scope of traditional Chinese medicine. Because of its multi-ingredient, multi-target, and multi-pathway characteristics, it has a great advantage in the treatment of liver cancer. Still, at present, its specific molecular mechanism of action has not yet been clarified.</p><p><strong>Aim: </strong>This study reviews the current status and characteristics of network pharmacology research in the treatment of liver cancer, aiming to provide new ideas and methods for traditional Chinese medicine treatment of the disease.</p><p><strong>Methods: </strong>This study was searched on the Web of Science and PubMed using keywords, such as \\\"traditional Chinese medicine\\\", \\\"liver cancer,\\\" and \\\"network pharmacology.\\\" The citation dates of the literature cited in this review are from 2000 to 2024.</p><p><strong>Results: </strong>The discovery of the key molecular mechanisms of traditional Chinese medicine in the treatment of liver cancer through the network pharmacology approach and the in-depth study of the related signaling pathways are conducive to a more in-depth exploration of traditional Chinese medicine.</p><p><strong>Conclusion: </strong>Network pharmacology research plays a key role in the treatment and prevention of liver cancer and deserves deeper exploration in the future.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266336478241118065659\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266336478241118065659","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
摘要
背景：肝癌是目前常见的恶性肿瘤之一，其发病的危险因素较多，具有复发率高、死亡率高、预后差等特点，对人们的健康构成了极大的威胁。中药的特殊疗效是建立在临床实践基础上的，是对处方药临床作用特点和范围的高度概括，是中药范围内人体医疗作用的特殊表现形式。由于其多成分、多靶点、多途径的特点，在治疗肝癌方面具有很大的优势。目的：本研究综述了网络药理学在肝癌治疗中的研究现状和特点，旨在为中药治疗肝癌提供新的思路和方法：本研究使用 "中医药"、"肝癌 "和 "网络药理学 "等关键词在 Web of Science 和 PubMed 上进行检索。本综述所引用文献的引用日期为 2000 年至 2024 年：结果：通过网络药理学方法发现中药治疗肝癌的关键分子机制，并深入研究相关信号通路，有利于对中药进行更深入的探索：网络药理学研究在肝癌的治疗和预防中发挥着关键作用，值得今后深入探索。
Traditional Chinese Medicine for Liver Cancer Treatment: Network Pharmacology Research.
Background: As one of the common malignant tumors nowadays, liver cancer has more risk factors for its development and is characterized by a high recurrence rate, high mortality rate, and poor prognosis, which poses a great threat to people's health. The specific efficacy of traditional Chinese medicine is based on clinical practice, which is a high degree of generalization of the characteristics and scope of the clinical effects of prescription medicines and a special form of expression of the medical effects of the human body within the scope of traditional Chinese medicine. Because of its multi-ingredient, multi-target, and multi-pathway characteristics, it has a great advantage in the treatment of liver cancer. Still, at present, its specific molecular mechanism of action has not yet been clarified.
Aim: This study reviews the current status and characteristics of network pharmacology research in the treatment of liver cancer, aiming to provide new ideas and methods for traditional Chinese medicine treatment of the disease.
Methods: This study was searched on the Web of Science and PubMed using keywords, such as "traditional Chinese medicine", "liver cancer," and "network pharmacology." The citation dates of the literature cited in this review are from 2000 to 2024.
Results: The discovery of the key molecular mechanisms of traditional Chinese medicine in the treatment of liver cancer through the network pharmacology approach and the in-depth study of the related signaling pathways are conducive to a more in-depth exploration of traditional Chinese medicine.
Conclusion: Network pharmacology research plays a key role in the treatment and prevention of liver cancer and deserves deeper exploration in the future.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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