以 Menin 为靶点，对高风险急性髓性白血病进行精准治疗。

IF 0.7 Q4 HEMATOLOGY Leukemia Research Reports Pub Date : 2025-01-01 DOI:10.1016/j.lrr.2024.100495

Abdur Jamil , Zaheer Qureshi , Zain Mary El-amir , Gillian Kupakuwana-Suk , Hamzah Akram , Mohsin Ahmad , Eric Huselton

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摘要

目的：这篇小型综述概述了Revumenib（一种一流的menin抑制剂）治疗KMT2A重排或NPM1突变的AML的现有证据。这种疗法通过选择性地破坏白血病发生途径代表了一种有希望的进步。总结：Revumenib在基因定义AML中的临床前景突出了其在塑造未来治疗前景方面的潜在作用。这一小型综述强调了正在进行的试验以确定最佳剂量、安全方案和联合治疗的必要性，最终目标是将Revumenib建立为高风险AML亚群的标准治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting menin for precision therapy in high-risk acute myeloid leukemia

Objective

This mini-review provides an overview of the current evidence for Revumenib, a first-in-class menin inhibitor, in treating AML with KMT2A rearrangements or NPM1 mutations. This therapy represents a promising advancement by selectively disrupting leukemogenic pathways.

Summary

The clinical promise of Revumenib in genetically defined AML highlights its potential role in shaping the future treatment landscape. This mini-review underscores the need for ongoing trials to define optimal dosing, safety protocols, and combination therapies, with the ultimate goal of establishing Revumenib as a standard of care for high-risk AML subsets.

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