治疗的实时镜像

IF 19.1 1区 生物学 Q1 CELL BIOLOGY Nature Cell Biology Pub Date : 2025-01-16 DOI:10.1038/s41556-024-01600-x
Stylianos Lefkopoulos
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引用次数: 0

摘要

对于侵袭性肿瘤,如胶质母细胞瘤,早期评估治疗效果是非常宝贵的。Logun等人从参与嵌合抗原受体(CAR) T细胞临床试验的患者身上生成胶质母细胞瘤类器官(GBOs),以实时监测治疗反应。作者获得了6例胶质母细胞瘤患者的肿瘤标本,这些患者参加了一期CAR - T细胞临床试验。使用先前报道的方案,他们在2-3周内从标本中培养出gbo,然后与患者匹配的CAR - T细胞共培养。这些gbo显示肿瘤细胞溶解。共培养6天后,Logun等人收集gbo并分析其靶抗原表达,发现目标抗原表达降低。最后,他们分析了CAR - T细胞- gbo共培养基,发现活化的T细胞持续释放细胞因子,这与患者体内CAR - T细胞活化的时间动力学相似。
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍: Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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