S. Shashidhar Bharadwaj, Boja Poojary, Sathish Kumar Boda, T. Shubhavathi, Vinuta Kamat, Bhuvanesh Sukhlal Kalal
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Anticancer activity of new quinolinyl–benzothiazolyl clubbed with amino acids and their in-silico studies
A lot of research is focused on creating novel chemotherapeutic medicines since cancer is becoming a more serious concern. In the present investigation, we have developed some quinolinyl–benzothiazolyl linked with amino acids and their anticancer efficacy against melanoma and breast cancer cells evaluated. All the compounds evaluated for in silico studies towards the target protein Human estrogen receptor (PDB: 2IOK). Out of all the evaluated aminoacids conjugates four compounds 5b, 5 k, 5f, and 5d exhibited remarkable docking scores and were chosen for in vitro anticancer studies. Out of which 5 k, and 5f exhibited good anticancer properties with the IC50[μg/mL] of 22.9 and 22.3 respectively against the melanoma cell line and 5b exhibited good anticancer properties with the IC50[μg/mL] of 61.0 against breast cancer cell.
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JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.
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