The preparation of methacrylated oxidized konjac glucomannan hydrogel system and its treatment for diabetic wounds.

The management of diabetic wounds has become an important task for the public health system. Hydrogels are highly anticipated as modern wound dressings for the treatment of diabetic wounds, hence we have prepared a MOK-Gel using methacrylated oxidized konjac glucomannan (MOK) crosslinked with acrylamide (AM). On this basis, we have incorporated drugs such as UiO-66 loaded with sodium ferulate (SF) and deferoxamine (DFO) to develop the hydrogel wound dressing DUS@MOK-Gel (a hydrogel composed of methacrylated oxidized konjac glucomannan, loaded with DFO and UiO-66 loaded with sodium ferulate). It not only has excellent physical properties, including swelling capacity, moisture retention, and water vapor permeability; but also possesses bioactivity functions such as antioxidant, anti-inflammatory, macrophage polarization regulation, promotion of anti-inflammatory factor release, and angiogenesis to accelerate the healing of diabetic wounds. Therefore, DUS@MOK-Gel has great development prospects and market value in the field of diabetic wound treatment.