Min Wang, Yanqing Zhang, Yaxin Li, Mengyu Zhang, Jinrui Liu, Yuxin Cao, Junbo Xie, Shuo Wang
{"title":"探索天然类黄酮在炎症性肠病中的治疗潜力：对肠黏膜屏障调节的见解。","authors":"Min Wang, Yanqing Zhang, Yaxin Li, Mengyu Zhang, Jinrui Liu, Yuxin Cao, Junbo Xie, Shuo Wang","doi":"10.2174/0115680266337430241127112031","DOIUrl":null,"url":null,"abstract":"<p><p>Inflammatory Bowel Disease (IBD) is a chronic non-specific disease that affects the gastrointestinal tract, and Intestinal Mucosal Barrier (IMB) damage is closely related to its pathogenesis. The management of IBD often involves repairing the mechanical, chemical, immune, or biological barriers of the intestinal mucosa to alleviate symptoms. Currently, the treatment of IBD patients requires continuous medication or surgical interventions, which can cause irreversible damage to the patient's body over time. Natural flavonoids, commonly found in human diets, offer a safe, effective, and non-toxic alternative, presenting significant potential for promoting intestinal health and disease prevention. This article aimed to explore current research concerning the role of natural flavonoids in modulating the IMB in IBD, offering a new perspective for the prevention and management of IBD and highlighting new opportunities for the development and application of natural flavonoids.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Therapeutic Potential of Natural Flavonoids in Inflammatory Bowel Disease: Insights into Intestinal Mucosal Barrier Regulation.\",\"authors\":\"Min Wang, Yanqing Zhang, Yaxin Li, Mengyu Zhang, Jinrui Liu, Yuxin Cao, Junbo Xie, Shuo Wang\",\"doi\":\"10.2174/0115680266337430241127112031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Inflammatory Bowel Disease (IBD) is a chronic non-specific disease that affects the gastrointestinal tract, and Intestinal Mucosal Barrier (IMB) damage is closely related to its pathogenesis. The management of IBD often involves repairing the mechanical, chemical, immune, or biological barriers of the intestinal mucosa to alleviate symptoms. Currently, the treatment of IBD patients requires continuous medication or surgical interventions, which can cause irreversible damage to the patient's body over time. Natural flavonoids, commonly found in human diets, offer a safe, effective, and non-toxic alternative, presenting significant potential for promoting intestinal health and disease prevention. This article aimed to explore current research concerning the role of natural flavonoids in modulating the IMB in IBD, offering a new perspective for the prevention and management of IBD and highlighting new opportunities for the development and application of natural flavonoids.</p>\",\"PeriodicalId\":11076,\"journal\":{\"name\":\"Current topics in medicinal chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current topics in medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2174/0115680266337430241127112031\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266337430241127112031","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Exploring the Therapeutic Potential of Natural Flavonoids in Inflammatory Bowel Disease: Insights into Intestinal Mucosal Barrier Regulation.
Inflammatory Bowel Disease (IBD) is a chronic non-specific disease that affects the gastrointestinal tract, and Intestinal Mucosal Barrier (IMB) damage is closely related to its pathogenesis. The management of IBD often involves repairing the mechanical, chemical, immune, or biological barriers of the intestinal mucosa to alleviate symptoms. Currently, the treatment of IBD patients requires continuous medication or surgical interventions, which can cause irreversible damage to the patient's body over time. Natural flavonoids, commonly found in human diets, offer a safe, effective, and non-toxic alternative, presenting significant potential for promoting intestinal health and disease prevention. This article aimed to explore current research concerning the role of natural flavonoids in modulating the IMB in IBD, offering a new perspective for the prevention and management of IBD and highlighting new opportunities for the development and application of natural flavonoids.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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