基于NHANES 2007-2020的成人甘油三酯葡萄糖指数相关指标与肾结石的关系

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM Frontiers in Endocrinology Pub Date : 2025-01-07 eCollection Date: 2024-01-01 DOI:10.3389/fendo.2024.1516982

Ming Liu, Ping Yang, Yunpeng Gou

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引用次数: 0

摘要

背景：甘油三酯-葡萄糖（TyG）指数及其相关指标，包括甘油三酯-葡萄糖体重指数（TyG- bmi）、甘油三酯-葡萄糖腰围（TyG- wc）和甘油三酯-葡萄糖腰高比（TyG- whtr），越来越被认为是胰岛素抵抗（IR）的有价值的标志物。本研究旨在评估这些tyg相关指标与肾结石之间的关系。方法：本横断面研究分析了2007年至2020年进行的国家健康与营养检查调查（NHANES）中10,824名参与者的数据。采用加权逻辑回归模型评估tyg相关指标与肾结石之间的关系，并对潜在的混杂因素进行调整。进行亚组分析和平滑曲线拟合以进一步检查这些关联，同时使用受试者工作特征（ROC）曲线来比较每个指标的预测性能。结果：当作为连续变量分析时，所有tyg相关指标均与肾结石呈显著正相关。TyG-BMI的比值比（OR）为1.0040 (1.0028,1.0052)，TyG-WC的比值比（OR）为1.0015 (1.0011,1.0020)，TyG-WHtR的比值比为1.3305（1.2277,1.4419）。在亚组和平滑曲线分析中也观察到类似的趋势。当按三分位数分层时，各tyg相关指数的高三分位数与肾结石的发病率增加有关。TyG- wc对肾结石的预测能力最强（AUC = 0.6158），其次是TyG- whtr （AUC = 0.6156）和TyG- bmi (AUC = 0.5949)，其中TyG的AUC最低（0.5815）。结论：本研究发现tyg相关指标与肾结石形成有显著正相关。其中TyG-WHtR对肾结石风险的预测能力最高。

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Association between triglyceride glucose index-related indices and kidney stones in adults based on NHANES 2007-2020.

Background: The triglyceride-glucose (TyG) index and related indices, including the triglyceride-glucose body mass index (TyG-BMI), triglyceride-glucose waist circumference (TyG-WC), and triglyceride-glucose waist-to-height ratio (TyG-WHtR), are increasingly recognized as valuable markers of insulin resistance (IR). This study aimed to assess the associations between these TyG-related indices and kidney stones.

Methods: This cross-sectional study analyzed data from 10,824 participants obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2020. Weighted logistic regression models were employed to evaluate the associations between TyG-related indices and kidney stones, with adjustments for potential confounding factors. Subgroup analyses and smooth curve fittings were performed to further examine these associations, while receiver operating characteristic (ROC) curves were used to compare the predictive performance of each index.

Results: All TyG-related indices demonstrated significant positive associations with kidney stones when analyzed as continuous variables. The odds ratios (OR) with 95% confidence intervals (CI) were 1.0040 (1.0028, 1.0052) for TyG-BMI, 1.0015 (1.0011, 1.0020) for TyG-WC, and 1.3305 (1.2277, 1.4419) for TyG-WHtR. Similar trends were observed in subgroup and smooth curve analyses. When stratified into tertiles, higher tertiles of each TyG-related index were associated with increased odds of kidney stones. TyG-WC demonstrated the strongest predictive capability for kidney stones (AUC = 0.6158), followed closely by TyG-WHtR (AUC = 0.6156) and TyG-BMI (AUC = 0.5949), with TyG showing the lowest AUC (0.5815).

Conclusion: This study identified significant positive associations between TyG-related indices and kidney stone formation. Among these indices, TyG-WHtR exhibited the highest predictive power for identifying kidney stone risk.

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.