Yan Liu , Junnan Li , Yan Sun , Juan Pan , Yumeng Luo , Wei Guan , Qingshan Chen , Lili Zhang , Anam Naseem , Haixue Kuang , Bingyou Yang
{"title":"三叶草色素及其对il -1β诱导的SW982细胞增殖活性的抑制作用。","authors":"Yan Liu , Junnan Li , Yan Sun , Juan Pan , Yumeng Luo , Wei Guan , Qingshan Chen , Lili Zhang , Anam Naseem , Haixue Kuang , Bingyou Yang","doi":"10.1016/j.phytochem.2025.114408","DOIUrl":null,"url":null,"abstract":"<div><div>Nine previously undescribed chromones, named sadivamones O–W (<strong>1</strong>–<strong>9</strong>), and five known analogues (<strong>10</strong>–<strong>14</strong>), were isolated from the roots of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk. The detailed structural analysis of each compound was finalized by a variety of methods including NMR (1D and 2D), mass spectrometry (HR-ESI-MS) spectroscopic data, and sugar hydrolysis. The absolute configurations of compounds (<strong>4</strong>–<strong>5</strong>) were determined by CD. Moreover, compounds <strong>1</strong>–<strong>14</strong> were evaluated for their inhibition of IL-1<em>β</em>-induced proliferative activity in SW982 cells. The results demonstrated that compounds <strong>2</strong>–<strong>4</strong> and <strong>11</strong>–<strong>12</strong> exhibited notable inhibitory effects on IL-1<em>β</em>-induced proliferation in a concentration-dependent manner, with the most pronounced inhibition observed at a concentration of 20 μM.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"233 ","pages":"Article 114408"},"PeriodicalIF":3.2000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chromones from Saposhnikovia divaricata and their inhibition of IL-1β-induced proliferative activity in SW982 cells\",\"authors\":\"Yan Liu , Junnan Li , Yan Sun , Juan Pan , Yumeng Luo , Wei Guan , Qingshan Chen , Lili Zhang , Anam Naseem , Haixue Kuang , Bingyou Yang\",\"doi\":\"10.1016/j.phytochem.2025.114408\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Nine previously undescribed chromones, named sadivamones O–W (<strong>1</strong>–<strong>9</strong>), and five known analogues (<strong>10</strong>–<strong>14</strong>), were isolated from the roots of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk. The detailed structural analysis of each compound was finalized by a variety of methods including NMR (1D and 2D), mass spectrometry (HR-ESI-MS) spectroscopic data, and sugar hydrolysis. The absolute configurations of compounds (<strong>4</strong>–<strong>5</strong>) were determined by CD. Moreover, compounds <strong>1</strong>–<strong>14</strong> were evaluated for their inhibition of IL-1<em>β</em>-induced proliferative activity in SW982 cells. The results demonstrated that compounds <strong>2</strong>–<strong>4</strong> and <strong>11</strong>–<strong>12</strong> exhibited notable inhibitory effects on IL-1<em>β</em>-induced proliferation in a concentration-dependent manner, with the most pronounced inhibition observed at a concentration of 20 μM.</div></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":\"233 \",\"pages\":\"Article 114408\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-01-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942225000317\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942225000317","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Chromones from Saposhnikovia divaricata and their inhibition of IL-1β-induced proliferative activity in SW982 cells
Nine previously undescribed chromones, named sadivamones O–W (1–9), and five known analogues (10–14), were isolated from the roots of Saposhnikovia divaricata (Turcz.) Schischk. The detailed structural analysis of each compound was finalized by a variety of methods including NMR (1D and 2D), mass spectrometry (HR-ESI-MS) spectroscopic data, and sugar hydrolysis. The absolute configurations of compounds (4–5) were determined by CD. Moreover, compounds 1–14 were evaluated for their inhibition of IL-1β-induced proliferative activity in SW982 cells. The results demonstrated that compounds 2–4 and 11–12 exhibited notable inhibitory effects on IL-1β-induced proliferation in a concentration-dependent manner, with the most pronounced inhibition observed at a concentration of 20 μM.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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