JAK抑制剂治疗的类风湿关节炎相关间质性肺疾病的评估:MAJIK-SFR队列研究

IF 5.1 2区 医学 Q1 RHEUMATOLOGY RMD Open Pub Date : 2025-01-06 DOI:10.1136/rmdopen-2024-005062
Félicien Triboulet, Pierre-Antoine Juge, Marie-Elise Truchetet, Thao Pham, Nicolas Roux, René-Marc Flipo, Charles Leské, Christian Hubert Roux, Raphaele Seror, André Basch, Olivier Brocq, Pascal Chazerain, Fabienne Coury-Lucas, Richard Damade, Emanuelle Dernis, Jacques-Eric Gottenberg, André Ramon, Adeline Ruyssen-Witrand, Jean Hugues Salmon, Émilie Shipley, Anne Tournadre, Clement Prati, Philippe Dieudé, Jerome Avouac
{"title":"JAK抑制剂治疗的类风湿关节炎相关间质性肺疾病的评估:MAJIK-SFR队列研究","authors":"Félicien Triboulet, Pierre-Antoine Juge, Marie-Elise Truchetet, Thao Pham, Nicolas Roux, René-Marc Flipo, Charles Leské, Christian Hubert Roux, Raphaele Seror, André Basch, Olivier Brocq, Pascal Chazerain, Fabienne Coury-Lucas, Richard Damade, Emanuelle Dernis, Jacques-Eric Gottenberg, André Ramon, Adeline Ruyssen-Witrand, Jean Hugues Salmon, Émilie Shipley, Anne Tournadre, Clement Prati, Philippe Dieudé, Jerome Avouac","doi":"10.1136/rmdopen-2024-005062","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.</p><p><strong>Methods: </strong>Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.</p><p><strong>Results: </strong>We enrolled 42 patients (26 women, 62%) with RA-ILD with a mean age of 61±13 years and a mean disease duration of 16±10 years. Compared with the 778 RA patients without ILD from the MAJIK registry, RA-ILD patients were older, displayed more severe and active disease and had more prevalent comorbidities. Non-specific interstitial pneumonia and usual interstitial pneumonia accounted for 46% and 43% of the chest HRCT ILD patterns, respectively. No significant changes in FVC and DLCO were observed during the follow-up period. Chest HRCT lesions remained stable in 69% of patients. Progressive ILD was identified in 8 patients (19%). 16 (38%) respiratory tract infections were observed. Only one acute regressive exacerbation of ILD was noted, and no lung cancer was diagnosed. No deaths occurred. JAKi was discontinued in 17 patients including 8 for inefficacy on joint involvement and 5 for intolerance.</p><p><strong>Conclusion: </strong>The analysis indicates stability of RA-ILD in patients treated with JAKi. The tolerance profile of JAKi in this higher risk population did not reveal new safety signal.</p>","PeriodicalId":21396,"journal":{"name":"RMD Open","volume":"11 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749054/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study.\",\"authors\":\"Félicien Triboulet, Pierre-Antoine Juge, Marie-Elise Truchetet, Thao Pham, Nicolas Roux, René-Marc Flipo, Charles Leské, Christian Hubert Roux, Raphaele Seror, André Basch, Olivier Brocq, Pascal Chazerain, Fabienne Coury-Lucas, Richard Damade, Emanuelle Dernis, Jacques-Eric Gottenberg, André Ramon, Adeline Ruyssen-Witrand, Jean Hugues Salmon, Émilie Shipley, Anne Tournadre, Clement Prati, Philippe Dieudé, Jerome Avouac\",\"doi\":\"10.1136/rmdopen-2024-005062\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.</p><p><strong>Methods: </strong>Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.</p><p><strong>Results: </strong>We enrolled 42 patients (26 women, 62%) with RA-ILD with a mean age of 61±13 years and a mean disease duration of 16±10 years. Compared with the 778 RA patients without ILD from the MAJIK registry, RA-ILD patients were older, displayed more severe and active disease and had more prevalent comorbidities. Non-specific interstitial pneumonia and usual interstitial pneumonia accounted for 46% and 43% of the chest HRCT ILD patterns, respectively. No significant changes in FVC and DLCO were observed during the follow-up period. Chest HRCT lesions remained stable in 69% of patients. Progressive ILD was identified in 8 patients (19%). 16 (38%) respiratory tract infections were observed. Only one acute regressive exacerbation of ILD was noted, and no lung cancer was diagnosed. No deaths occurred. JAKi was discontinued in 17 patients including 8 for inefficacy on joint involvement and 5 for intolerance.</p><p><strong>Conclusion: </strong>The analysis indicates stability of RA-ILD in patients treated with JAKi. The tolerance profile of JAKi in this higher risk population did not reveal new safety signal.</p>\",\"PeriodicalId\":21396,\"journal\":{\"name\":\"RMD Open\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-01-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749054/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RMD Open\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1136/rmdopen-2024-005062\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RMD Open","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/rmdopen-2024-005062","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:通过MAJIK-SFR登记,研究在法国接受Janus激酶抑制剂(JAKis)治疗的类风湿性关节炎(RA-ILD)相关间质性肺疾病的病程。方法:前瞻性国家多中心观察研究,从MAJIK-SFR登记中识别RA-ILD患者。在JAKi开始和随访时(纳入后6个月、12个月和中位21个月)收集肺部评估数据,包括胸部高分辨率CT (HRCT)、肺功能测试(用力肺活量(FVC)和肺一氧化碳弥散量(DLCO))、ILD急性加重、呼吸道感染和肺癌。结果:我们纳入了42例RA-ILD患者(26例女性,62%),平均年龄61±13岁,平均病程16±10年。与MAJIK登记的778名无ILD的RA患者相比,RA-ILD患者年龄更大,表现出更严重和活动性的疾病,并有更普遍的合并症。非特异性间质性肺炎和常规间质性肺炎分别占胸部HRCT ILD类型的46%和43%。随访期间FVC和DLCO无明显变化。69%的患者胸部HRCT病变保持稳定。8例(19%)患者被确诊为进行性ILD。呼吸道感染16例(38%)。只有一个急性退行性恶化的ILD被注意到,没有肺癌的诊断。没有人员死亡。17例患者停用了JAKi,其中8例因关节受累无效,5例因不耐受。结论:分析表明JAKi患者RA-ILD的稳定性。在这一高危人群中,JAKi耐受性特征并没有显示出新的安全性信号。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study.

Objective: To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.

Methods: Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.

Results: We enrolled 42 patients (26 women, 62%) with RA-ILD with a mean age of 61±13 years and a mean disease duration of 16±10 years. Compared with the 778 RA patients without ILD from the MAJIK registry, RA-ILD patients were older, displayed more severe and active disease and had more prevalent comorbidities. Non-specific interstitial pneumonia and usual interstitial pneumonia accounted for 46% and 43% of the chest HRCT ILD patterns, respectively. No significant changes in FVC and DLCO were observed during the follow-up period. Chest HRCT lesions remained stable in 69% of patients. Progressive ILD was identified in 8 patients (19%). 16 (38%) respiratory tract infections were observed. Only one acute regressive exacerbation of ILD was noted, and no lung cancer was diagnosed. No deaths occurred. JAKi was discontinued in 17 patients including 8 for inefficacy on joint involvement and 5 for intolerance.

Conclusion: The analysis indicates stability of RA-ILD in patients treated with JAKi. The tolerance profile of JAKi in this higher risk population did not reveal new safety signal.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
RMD Open
RMD Open RHEUMATOLOGY-
CiteScore
7.30
自引率
6.50%
发文量
205
审稿时长
14 weeks
期刊介绍: RMD Open publishes high quality peer-reviewed original research covering the full spectrum of musculoskeletal disorders, rheumatism and connective tissue diseases, including osteoporosis, spine and rehabilitation. Clinical and epidemiological research, basic and translational medicine, interesting clinical cases, and smaller studies that add to the literature are all considered.
期刊最新文献
Associations of sociodemographic, clinical factors and HLA-B alleles with enthesitis and peripheral arthritis in patients with ankylosing spondylitis. Cardiovascular events in patients with myositis: results from a French retrospective cohort. Rheumatoid arthritis and psoriatic arthritis: is the disease impact different? A large matching study at diagnosis and after 1 year of treatment. Transcriptome analysis to decipher the molecular underpinnings of response to treatment in systemic lupus erythematosus. Holistic approaches in systemic lupus erythematosus: do physicians avoid addressing difficult-to-treat but highly relevant symptoms?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1