犬颅内脑膜瘤的早期迟发性放射毒性与每日6 Gy × 5 (30 Gy)立体定向放射治疗相关。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2025-01-19 DOI:10.1111/vco.13040
James Elliott
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引用次数: 0

摘要

1-3组分立体定向放射治疗(SRT)治疗犬颅内脑膜瘤后的早期延迟副作用(EDSEs)可导致神经系统体征恶化,减轻这种毒性的一种潜在方法是减少每组分的剂量。20只经影像学诊断为颅内脑膜瘤的狗接受6 Gy × 5,每日(30 Gy)的电话随访,随访时间至少6个月。“可能的EDSE”定义为在完成SRT后1-4个月内出现的精神迟钝、现有神经系统体征的神经系统恶化或新出现的神经系统体征,无论对类固醇的反应如何,即使没有进行MRI检查。“可能的EDSE”被定义为精神迟钝,现有神经症状的神经系统恶化或完成SRT后1-4个月内出现的新神经症状。这些症状随着强的松龙的开始或剂量的增加是可逆的,或者后续的MRI没有发现其他解释的证据。没有狗出现急性放射毒性或与EDSEs相符的临床症状。该方案似乎导致有限的急性放射毒性,应进一步评估长期毒性的频率和相对疗效。
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Early-Delayed Radiotoxicity Associated With Stereotactic Radiation Therapy Following a Daily 6 Gy × 5 (30 Gy) Protocol for Presumed Canine Intracranial Meningiomas.

Early-delayed side effects (EDSEs) following treatment of canine intracranial meningiomas with 1-3-fraction stereotactic radiation therapy (SRT) can cause worsening neurologic signs, and one potential method of mitigating this toxicity is reducing the dose per fraction. Twenty dogs with imaging-diagnosed intracranial meningiomas and telephone follow-up of at least 6 months received a protocol of 6 Gy × 5, daily (30 Gy). A 'possible EDSE' was defined as mental dullness, neurologic exacerbation of existing neurologic signs or new neurologic signs occurring within 1-4 months of completing SRT, regardless of the response to steroids and even if an MRI was not performed. A 'probable EDSE' was defined as mental dullness, neurologic exacerbation of existing neurologic signs or new neurologic signs occurring within 1-4 months of completing SRT. These signs were either reversible with the initiation or increased doses of prednisolone, or follow-up MRI revealed no evidence of an alternate explanation. No dogs experienced acute radiotoxicity or clinical signs compatible with EDSEs. The protocol appears to result in limited acute radiotoxicity, and further evaluation of the frequency of long-term toxicities and relative efficacy should be undertaken.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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