[老年人抗胆碱能负荷]。

IF 0.6 Q4 HEALTH POLICY & SERVICES Farmaceuticos Comunitarios Pub Date : 2024-11-25 eCollection Date: 2025-01-15 DOI:10.33620/FC.2173-9218.(2025).02
M Rodríguez Casal
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引用次数: 0

摘要

抗胆碱能药物广泛用于帕金森病、抑郁症或过敏等非常常见的疾病,但在以往的研究中观察到,高抗胆碱能负担可导致多药老年人的身体和认知功能障碍。本项目的目的是回顾这些假设,并研究高抗胆碱能负荷与认知和身体功能障碍之间的可能关系。在方法学方面,对迄今为止存在的信息进行了文献回顾,假设高抗胆碱能负担会导致服用多种药物的老年人的身体和认知功能障碍,一项横断面研究包括70岁以上服用多种药物的患者来计算他们药物的抗胆碱能负荷,并确定高水平的抗胆碱能是否会对患者的病情恶化产生影响。在研究结束时,观察到老年患者中高抗胆碱能负担药物的处方患病率高,其后果是不良反应。这些结果使我们得出结论,在开处方时需要考虑药物的抗胆碱能负担。
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[Anticholinergic burden in the elderly].

Anticholinergic drugs are widely used for very common diseases such as Parkinson's disease, depression or allergies, but it has been observed in previous studies that high anticholinergic burden can lead to physical and cognitive dysfunctions in polymedicated elderly people. The objective of this project is to review these hypotheses and study the possible relationship between high anticholinergic burden and cognitive and physical dysfunctions.In terms of methodology, a bibliographic review has been carried out of the information that exists to date on the hypothesis that high anticholinergic burden can lead to both physical and cognitive dysfunctions in elderly people taking multiple medications, and a cross-sectional study has been designed that included patients over 70 years and taking multiple medications to calculate the anticholinergic burden of their medication and determine whether high levels of it could have any influence on the deterioration of the patients.At the end of the study, it was observed high prevalence of prescriptions of medications with high anticholinergic burden in elderly patients, with its consequences in terms of adverse effects. These results lead us to the conclusion of the need to take into account the anticholinergic burden of medications when prescribing.

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来源期刊
Farmaceuticos Comunitarios
Farmaceuticos Comunitarios HEALTH POLICY & SERVICES-
CiteScore
0.40
自引率
33.30%
发文量
351
审稿时长
5 weeks
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