Risk of Dementia and Its Associated Factors Among the Patients With Coronary Artery Disease Attending a Tertiary Cardiac Hospital of Dhaka City: A Cross-Sectional Study.

Background and aims: In Bangladesh, data related to the future risk of dementia and its associated factors are scarce. Furthermore, no dementia risk prediction tool has yet been applied to estimate the risk in any population in Bangladesh. Therefore, our objective was to assess the risk of dementia and its associated factors among patients with coronary artery disease (CAD).

Methods: This cross-sectional study conveniently recruited 280 stable patients with CAD who were admitted for coronary revascularization at a tertiary cardiac hospital situated in Dhaka, Bangladesh. Data were collected face-to-face using a pretested questionnaire adapted from the WHO STEP-wise Approach to Surveillance (STEPS) of Noncommunicable Diseases Risk Factors questionnaire (Version 3.2). The questionnaire included background information (sociodemographic, comorbidity), behavioral and metabolic risk factors, physical and biochemical measurements. The next 20 years' risk of dementia was estimated using the "Cardiovascular Risk Factors, Aging, and Incidence of Dementia" score. The risk score, risk levels, and risk factors were presented descriptively. The associated factors of dementia risk were elucidated using hierarchical multiple regression analysis.

Results: The mean ( ± standard deviation) risk score for dementia was 6.26 ± 2.28. The predicted "at-risk" population was 63.6%. The prevalent risk factors were unhealthy diets (84.3%) presented by inadequate fruit/vegetable consumption (70%) and added salt intake (46.4%). In the final model of hierarchical multiple regression, the risk score showed a significant association with several risk factors: family history of diabetes (p = 0.03), alcohol intake (p = 0.03), current smoking (p = 0.03), estimated glomerular filtration rate (p = 0.001), and diastolic blood pressure (p = 0.02).

Conclusion: A substantial proportion of patients with CAD had a future risk of dementia which demands an urgent risk reduction strategy in Bangladesh. Future longitudinal studies may more precisely justify the current findings.