The recent (2018-2022) US monthly mortality for acute myocardial infarction still peaks in December and January.

Purpose: To verify whether the trend of AMI mortality throughout the different months of the year may have recently changed in the US due to the coronavirus disease 2019 (COVID-19) pandemic and climate changes.

Methods: We examined monthly mortality trends for acute myocardial infarction (AMI) in the U.S. from 2018 to 2022 by conducting an electronic search of the latest version of the CDC Wonder (Wide-Ranging, Online Data for Epidemiologic Research) online database. We calculated and analyzed the mean and standard deviation (SD) of cumulative AMI deaths each month from 2018 to 2022.

Results: We observed a notable seasonal pattern, with mortality peaking in December and January and dropping from June to September. AMI-related deaths were significantly higher in January compared to other months, except December, with no significant difference between December and January (p = 0.868). The lowest mortality rates were observed in summer, with a marked decline between March and September. Statistically, the monthly variation in mean AMI deaths was significant (ANOVA, f = 13.1, p < 0.001).

Conclusion: Healthcare systems should allocate resources effectively during winter to manage this seasonal burden.