Pub Date : 2026-02-07DOI: 10.1016/j.amjmed.2026.01.052
Ralph I Horwitz, Allison Hayes Conroy, Mark R Cullen, Ida Sim
The debate over whether obesity constitutes disease reveals a fundamental limitation in biomedical disease models. We propose a bio-biographical framework recognizing that disease emerges when biological processes and biographical context, including for example lived experience, social position, chronic stressors, trauma, couple together to generate present or potential harm meaningful to the person. Biography is not external to disease but constitutive of it, shaping causation, expression, and trajectory through embodied mechanisms. This reconceptualization applies beyond obesity to cancer, cardiovascular disease, neurodegeneration and more, offering a new foundation for medicine that acknowledges both biological mechanisms and disrupted human lives.
{"title":"Reconceptualizing Obesity and the Modern Definition of Disease.","authors":"Ralph I Horwitz, Allison Hayes Conroy, Mark R Cullen, Ida Sim","doi":"10.1016/j.amjmed.2026.01.052","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.052","url":null,"abstract":"<p><p>The debate over whether obesity constitutes disease reveals a fundamental limitation in biomedical disease models. We propose a bio-biographical framework recognizing that disease emerges when biological processes and biographical context, including for example lived experience, social position, chronic stressors, trauma, couple together to generate present or potential harm meaningful to the person. Biography is not external to disease but constitutive of it, shaping causation, expression, and trajectory through embodied mechanisms. This reconceptualization applies beyond obesity to cancer, cardiovascular disease, neurodegeneration and more, offering a new foundation for medicine that acknowledges both biological mechanisms and disrupted human lives.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-07DOI: 10.1016/j.amjmed.2026.02.009
Isaac Ks Ng, Jiali Wang, Cheryl Kt Chua
{"title":"Vision on the Line: Central Retinal Artery Occlusion as the Presenting Complaint in Granulomatous Polyangiitis.","authors":"Isaac Ks Ng, Jiali Wang, Cheryl Kt Chua","doi":"10.1016/j.amjmed.2026.02.009","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.02.009","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-07DOI: 10.1016/j.amjmed.2026.01.055
Adrián Arapiles-Muñoz, Carlos Pestana Soares, Teresa Reina Durán, Jorge Polo Sabau
{"title":"When innocent symptoms unmask the mimicker: a 50-year-old man with recurrent abdominal pain.","authors":"Adrián Arapiles-Muñoz, Carlos Pestana Soares, Teresa Reina Durán, Jorge Polo Sabau","doi":"10.1016/j.amjmed.2026.01.055","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.055","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1016/j.amjmed.2026.01.038
Brandon J Zaffuto, Barat S Venkataramany
{"title":"Acing the Interview - Theory-based Strategies to Improve Interview Performance in the Medical Professions.","authors":"Brandon J Zaffuto, Barat S Venkataramany","doi":"10.1016/j.amjmed.2026.01.038","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.038","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.amjmed.2026.01.039
Mohammed Ayyad, Juan Bello, Daniel Matassa
{"title":"Are Residency Classes Diverse Enough?","authors":"Mohammed Ayyad, Juan Bello, Daniel Matassa","doi":"10.1016/j.amjmed.2026.01.039","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.039","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1016/j.amjmed.2026.01.016
Daniel E Forman, Robert M Carey, Starr Block, Steve Dentel, Deena Goldwater, Paul Heidenreich, Jean Luciano, Steven V Manoukian, J Mocco, Srinivas Murali, D P Suresh, Kathie Thomas, Cory W Woods, Alice K Jacobs
{"title":"Advancing Quality in Post-Acute Cardiovascular and Stroke Care: Why National Leadership and Certification Matter.","authors":"Daniel E Forman, Robert M Carey, Starr Block, Steve Dentel, Deena Goldwater, Paul Heidenreich, Jean Luciano, Steven V Manoukian, J Mocco, Srinivas Murali, D P Suresh, Kathie Thomas, Cory W Woods, Alice K Jacobs","doi":"10.1016/j.amjmed.2026.01.016","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.016","url":null,"abstract":"","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1016/j.amjmed.2026.01.018
Rendelle Bolton, Kelly Dvorin, Juliet Wu, Erum Abedin, Varsha Vimalananda
Purpose: VA's Clinical Resource Hubs (CRH) are well-positioned to fill pain care gaps experienced by rural-dwelling patients through regional hub-and-spoke models. We examined how CRHs integrated Whole Health approaches to expand access to this care for chronic pain.
Methods: Qualitative interviews conducted with employees in 4 CRHs were rapidly analyzed to examine how CRHs organized and delivered Whole Health care.
Results: CRH's delivered Whole Health care in interdisciplinary pain, stand-alone Whole Health, and primary care clinics. All offered varied Whole Health services (Whole Health coaching, complementary and integrative health therapies, and Whole Health groups), and incorporated key elements of person-centered communication to ensure care aligned with what mattered most to patients. Considerations unique to CRH delivery included multiple referral pathways, orienting patients to this short-term centralized care model, obtaining medical clearance, ensuring care continuity upon discharge, and telehealth adaptations. Participants perceived multiple benefits of Whole Health in CRHs for the healthcare system and patients.
Conclusions: Whole Health care can be successfully integrated into innovative centralized health system models like CRHs, enhancing accessibility. Replicating these models requires establishment of clear entry and discharge processes, and attention to virtual care delivery.
{"title":"Expanding Whole Health Access for Rural Veterans with Pain: Virtual Hub-and-Spoke Models.","authors":"Rendelle Bolton, Kelly Dvorin, Juliet Wu, Erum Abedin, Varsha Vimalananda","doi":"10.1016/j.amjmed.2026.01.018","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.018","url":null,"abstract":"<p><strong>Purpose: </strong>VA's Clinical Resource Hubs (CRH) are well-positioned to fill pain care gaps experienced by rural-dwelling patients through regional hub-and-spoke models. We examined how CRHs integrated Whole Health approaches to expand access to this care for chronic pain.</p><p><strong>Methods: </strong>Qualitative interviews conducted with employees in 4 CRHs were rapidly analyzed to examine how CRHs organized and delivered Whole Health care.</p><p><strong>Results: </strong>CRH's delivered Whole Health care in interdisciplinary pain, stand-alone Whole Health, and primary care clinics. All offered varied Whole Health services (Whole Health coaching, complementary and integrative health therapies, and Whole Health groups), and incorporated key elements of person-centered communication to ensure care aligned with what mattered most to patients. Considerations unique to CRH delivery included multiple referral pathways, orienting patients to this short-term centralized care model, obtaining medical clearance, ensuring care continuity upon discharge, and telehealth adaptations. Participants perceived multiple benefits of Whole Health in CRHs for the healthcare system and patients.</p><p><strong>Conclusions: </strong>Whole Health care can be successfully integrated into innovative centralized health system models like CRHs, enhancing accessibility. Replicating these models requires establishment of clear entry and discharge processes, and attention to virtual care delivery.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-28DOI: 10.1016/j.amjmed.2026.01.022
Daniel E Forman, Robert M Carey, Starr Block, Steve Dentel, Deena Goldwater, Paul Heidenreich, Jean Luciano, Steven V Manoukian, J Mocco, Srinivas Murali, D P Suresh, Kathie Thomas, Cory W Woods, Alice K Jacobs
Over 40% of patients are discharged to post-acute care services which serve predominantly older adults with cardiovascular or cerebrovascular disease and substantial age-related complexity. Post-acute care settings are often siloed from the broader healthcare system, creating care gaps, suboptimal outcomes, and higher-than-average readmission rates. As value-based care models increasingly emphasize holistic, equitable care for an aging population, Post-acute care represents a major opportunity for improvement, including the use of preventive strategies and standardized, evidence-based processes. Certification programs in post-acute care could strengthen patient and family engagement in prevention and wellness, integrate routine geriatric assessments, and promote consistent application of personalized clinical practice guidelines following cardiovascular events and stroke. The American Heart Association (AHA)/American Stroke Association (ASA) is well suited to lead this effort, with a strong history of building registries, accreditation frameworks, and recognition programs that elevate guideline-recommended heart and stroke care. Leveraging new tools and data systems, the AHA/ASA is generating the evidence needed to support widespread post-acute care certification, with the goal of improving care quality and long-term outcomes for patients transitioning from acute hospitalization.
{"title":"Post-Acute Cardiovascular and Stroke Care and the Potential of Certification Programs: A \"Call to Action\" Current Challenges of Post-Acute Care and Rationale for Certification.","authors":"Daniel E Forman, Robert M Carey, Starr Block, Steve Dentel, Deena Goldwater, Paul Heidenreich, Jean Luciano, Steven V Manoukian, J Mocco, Srinivas Murali, D P Suresh, Kathie Thomas, Cory W Woods, Alice K Jacobs","doi":"10.1016/j.amjmed.2026.01.022","DOIUrl":"https://doi.org/10.1016/j.amjmed.2026.01.022","url":null,"abstract":"<p><p>Over 40% of patients are discharged to post-acute care services which serve predominantly older adults with cardiovascular or cerebrovascular disease and substantial age-related complexity. Post-acute care settings are often siloed from the broader healthcare system, creating care gaps, suboptimal outcomes, and higher-than-average readmission rates. As value-based care models increasingly emphasize holistic, equitable care for an aging population, Post-acute care represents a major opportunity for improvement, including the use of preventive strategies and standardized, evidence-based processes. Certification programs in post-acute care could strengthen patient and family engagement in prevention and wellness, integrate routine geriatric assessments, and promote consistent application of personalized clinical practice guidelines following cardiovascular events and stroke. The American Heart Association (AHA)/American Stroke Association (ASA) is well suited to lead this effort, with a strong history of building registries, accreditation frameworks, and recognition programs that elevate guideline-recommended heart and stroke care. Leveraging new tools and data systems, the AHA/ASA is generating the evidence needed to support widespread post-acute care certification, with the goal of improving care quality and long-term outcomes for patients transitioning from acute hospitalization.</p>","PeriodicalId":50807,"journal":{"name":"American Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}