Vicente Molina , Inés Fernández-Linsenbarth , Rosa Beño-Ruiz- de- la- Sierra , Emma Osorio-Iriarte , Alejandro Roig , Antonio Arjona , Víctor Rodríguez , Pablo Núñez , Jesús Poza , Alvaro Díez-Revuelta , Claudia Rodríguez-Valbuena , Gema Mijancos-Martínez , Alejandro Bachiller , Miguel Angel Mañanas
{"title":"精神分裂症患者经颅磁刺激后微扰复杂性指数降低。","authors":"Vicente Molina , Inés Fernández-Linsenbarth , Rosa Beño-Ruiz- de- la- Sierra , Emma Osorio-Iriarte , Alejandro Roig , Antonio Arjona , Víctor Rodríguez , Pablo Núñez , Jesús Poza , Alvaro Díez-Revuelta , Claudia Rodríguez-Valbuena , Gema Mijancos-Martínez , Alejandro Bachiller , Miguel Angel Mañanas","doi":"10.1016/j.pnpbp.2025.111254","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Informational integration and differentiation of the cortex can be tested by methods such as the perturbational complexity index (PCI) combined with TMS-induced activity perturbation. The PCI is obtained by stimulating the cortex with TMS and measuring the resulting spatiotemporal cortical responses with high-density EEG.</div></div><div><h3>Methods</h3><div>We have compared PCI between 26 patients with schizophrenia (15 males), 15 of them First Episode (FE) (7 males), and 22 healthy controls (12 males).</div></div><div><h3>Results</h3><div>Values of PCI were significantly lower in patients with schizophrenia, as well as in FE considered alone. There was no significant relation between anomalous self-experiences or symptoms and PCI values in the patients: PCI values were unrelated to treatment doses or illness duration.</div></div><div><h3>Conclusions</h3><div>Our data suggest that spatiotemporal cortical responses to TMS pulses are reduced in patients regarding variability or spatial extension, which could imply a lower capacity for sustaining informational complexity.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"137 ","pages":"Article 111254"},"PeriodicalIF":5.3000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Lower perturbational complexity index after transcranial magnetic stimulation in schizophrenia patients\",\"authors\":\"Vicente Molina , Inés Fernández-Linsenbarth , Rosa Beño-Ruiz- de- la- Sierra , Emma Osorio-Iriarte , Alejandro Roig , Antonio Arjona , Víctor Rodríguez , Pablo Núñez , Jesús Poza , Alvaro Díez-Revuelta , Claudia Rodríguez-Valbuena , Gema Mijancos-Martínez , Alejandro Bachiller , Miguel Angel Mañanas\",\"doi\":\"10.1016/j.pnpbp.2025.111254\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Informational integration and differentiation of the cortex can be tested by methods such as the perturbational complexity index (PCI) combined with TMS-induced activity perturbation. The PCI is obtained by stimulating the cortex with TMS and measuring the resulting spatiotemporal cortical responses with high-density EEG.</div></div><div><h3>Methods</h3><div>We have compared PCI between 26 patients with schizophrenia (15 males), 15 of them First Episode (FE) (7 males), and 22 healthy controls (12 males).</div></div><div><h3>Results</h3><div>Values of PCI were significantly lower in patients with schizophrenia, as well as in FE considered alone. There was no significant relation between anomalous self-experiences or symptoms and PCI values in the patients: PCI values were unrelated to treatment doses or illness duration.</div></div><div><h3>Conclusions</h3><div>Our data suggest that spatiotemporal cortical responses to TMS pulses are reduced in patients regarding variability or spatial extension, which could imply a lower capacity for sustaining informational complexity.</div></div>\",\"PeriodicalId\":54549,\"journal\":{\"name\":\"Progress in Neuro-Psychopharmacology & Biological Psychiatry\",\"volume\":\"137 \",\"pages\":\"Article 111254\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-01-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Neuro-Psychopharmacology & Biological Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0278584625000089\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278584625000089","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Lower perturbational complexity index after transcranial magnetic stimulation in schizophrenia patients
Background
Informational integration and differentiation of the cortex can be tested by methods such as the perturbational complexity index (PCI) combined with TMS-induced activity perturbation. The PCI is obtained by stimulating the cortex with TMS and measuring the resulting spatiotemporal cortical responses with high-density EEG.
Methods
We have compared PCI between 26 patients with schizophrenia (15 males), 15 of them First Episode (FE) (7 males), and 22 healthy controls (12 males).
Results
Values of PCI were significantly lower in patients with schizophrenia, as well as in FE considered alone. There was no significant relation between anomalous self-experiences or symptoms and PCI values in the patients: PCI values were unrelated to treatment doses or illness duration.
Conclusions
Our data suggest that spatiotemporal cortical responses to TMS pulses are reduced in patients regarding variability or spatial extension, which could imply a lower capacity for sustaining informational complexity.
期刊介绍：
Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject.
Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.
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