Jiale Gan , Xinyi Yang , Jianan Wu , Peiyi Mo , Yongxing Deng , Yan Liu , Yang Wu , Peian Liu , Lianhong Ji , Hui Jiang , Yunfei Han , Zhaoyao Chen , Wenlei Li , Yuan Zhu , Minghua Wu
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The purpose of this study was to elucidate the connection between BRI and the general incidence of stroke in the US population.</div></div><div><h3>Design, Setting, and Participants</h3><div>This cohort study extracted cross-sectional data from 39,454 U.S. adults (aged ≥20 years) from documents related to the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2018.</div></div><div><h3>Methods</h3><div>We evaluated the relationship between BRI and stroke using weighted logistic regression analysis, and we looked at any possible nonlinear relationships using restricted cubic spline (RCS) regression. Additionally, subgroup analysis and interaction tests were carried out.</div></div><div><h3>Results</h3><div>The study involved 39,454 participants, of whom 1,427 (3.6 %) had a stroke. Fully adjusted logistic regression models showed that BRI was positively associated with stroke, with a 5.7 % increase in stroke incidence per unit increase in BRI (OR = 1.057, 95 % CI = 1.009,1.108, <em>P</em> = 0.020). RCS analysis revealed a nonlinear association, suggesting an elevated risk of stroke before the inflection point of 8.489. This positive correlation was consistent across settings, according to subgroup analyses and interaction tests (<em>P</em> > 0.05 for all interactions).</div></div><div><h3>Conclusions and relevance</h3><div>There is a nonlinear positive correlation between BRI and stroke, according to this national cohort study. These results support the use of the BRI as a screening tool for assessing stroke risk; yet, because cross-sectional studies have inherent limitations, more thorough research is required until the BRI has been consistently validated in additional independent cohorts.</div></div>","PeriodicalId":54368,"journal":{"name":"Journal of Stroke & Cerebrovascular Diseases","volume":"34 3","pages":"Article 108243"},"PeriodicalIF":2.0000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between body roundness index and stroke results from the 1999-2018 NHANES\",\"authors\":\"Jiale Gan , Xinyi Yang , Jianan Wu , Peiyi Mo , Yongxing Deng , Yan Liu , Yang Wu , Peian Liu , Lianhong Ji , Hui Jiang , Yunfei Han , Zhaoyao Chen , Wenlei Li , Yuan Zhu , Minghua Wu\",\"doi\":\"10.1016/j.jstrokecerebrovasdis.2025.108243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Importance</h3><div>Obesity, especially visceral obesity, is a controllable risk factor associated with the incidence of stroke. The body roundness index (BRI) bridges the gap between traditional anthropometric methods of assessing fat distribution to predict the percentage of body fat and visceral adipose tissue, which can be used to decipher its population-based characteristics and potential association with stroke.</div></div><div><h3>Objective</h3><div>The negative impact of accumulated visceral obesity on cerebrovascular health has been widely documented. However, the association between BRI and stroke has never been reported before. 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Fully adjusted logistic regression models showed that BRI was positively associated with stroke, with a 5.7 % increase in stroke incidence per unit increase in BRI (OR = 1.057, 95 % CI = 1.009,1.108, <em>P</em> = 0.020). RCS analysis revealed a nonlinear association, suggesting an elevated risk of stroke before the inflection point of 8.489. This positive correlation was consistent across settings, according to subgroup analyses and interaction tests (<em>P</em> > 0.05 for all interactions).</div></div><div><h3>Conclusions and relevance</h3><div>There is a nonlinear positive correlation between BRI and stroke, according to this national cohort study. 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引用次数: 0
摘要
重要性：肥胖，尤其是内脏肥胖，是与卒中发病率相关的可控危险因素。身体圆度指数（BRI）弥补了评估脂肪分布的传统人体测量方法之间的差距，以预测身体脂肪和内脏脂肪组织的百分比，可用于解读其基于人群的特征及其与中风的潜在关联。目的：积累性内脏性肥胖对脑血管健康的负面影响已被广泛报道。然而，BRI与中风之间的关联从未被报道过。本研究的目的是阐明在美国人群中BRI与卒中一般发病率之间的联系。设计、环境和参与者：本队列研究从1999年至2018年的国家健康与营养检查调查（NHANES）相关文件中提取了39,454名美国成年人（年龄≥20岁）的横断面数据。方法：我们使用加权逻辑回归分析评估BRI与卒中之间的关系，并使用限制三次样条（RCS）回归研究任何可能的非线性关系。此外，还进行了亚组分析和交互作用试验。结果：该研究涉及39,454名参与者，其中1,427名（3.6%）患有中风。完全调整后的logistic回归模型显示BRI与卒中呈正相关，BRI每增加一个单位卒中发生率增加5.7% （OR = 1.057, 95% CI = 1.009,1.108, P = 0.020）。RCS分析显示出一种非线性关联，提示在8.489拐点之前卒中风险升高。根据亚组分析和相互作用试验，这种正相关性在不同设置下是一致的（所有相互作用的P < 0.05）。结论和相关性：根据这项国家队列研究，BRI和卒中之间存在非线性正相关。这些结果支持使用BRI作为评估卒中风险的筛查工具；然而，由于横断面研究具有固有的局限性，在BRI在其他独立队列中得到一致验证之前，需要进行更彻底的研究。
Association between body roundness index and stroke results from the 1999-2018 NHANES
Importance
Obesity, especially visceral obesity, is a controllable risk factor associated with the incidence of stroke. The body roundness index (BRI) bridges the gap between traditional anthropometric methods of assessing fat distribution to predict the percentage of body fat and visceral adipose tissue, which can be used to decipher its population-based characteristics and potential association with stroke.
Objective
The negative impact of accumulated visceral obesity on cerebrovascular health has been widely documented. However, the association between BRI and stroke has never been reported before. The purpose of this study was to elucidate the connection between BRI and the general incidence of stroke in the US population.
Design, Setting, and Participants
This cohort study extracted cross-sectional data from 39,454 U.S. adults (aged ≥20 years) from documents related to the National Health and Nutrition Examination Survey (NHANES) from 1999 through 2018.
Methods
We evaluated the relationship between BRI and stroke using weighted logistic regression analysis, and we looked at any possible nonlinear relationships using restricted cubic spline (RCS) regression. Additionally, subgroup analysis and interaction tests were carried out.
Results
The study involved 39,454 participants, of whom 1,427 (3.6 %) had a stroke. Fully adjusted logistic regression models showed that BRI was positively associated with stroke, with a 5.7 % increase in stroke incidence per unit increase in BRI (OR = 1.057, 95 % CI = 1.009,1.108, P = 0.020). RCS analysis revealed a nonlinear association, suggesting an elevated risk of stroke before the inflection point of 8.489. This positive correlation was consistent across settings, according to subgroup analyses and interaction tests (P > 0.05 for all interactions).
Conclusions and relevance
There is a nonlinear positive correlation between BRI and stroke, according to this national cohort study. These results support the use of the BRI as a screening tool for assessing stroke risk; yet, because cross-sectional studies have inherent limitations, more thorough research is required until the BRI has been consistently validated in additional independent cohorts.
期刊介绍：
The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.
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