[20岁以下人群的免疫性血小板减少症:卡萨布兰卡儿科血液学和肿瘤科的十年经验]。

Revue medicale de Liege Pub Date : 2025-01-01
Amine Benmoussa, Fatima Zahra Loukal, Nizar Dahmaoui, Siham Cherkaoui, Mouna Lamchaheb, Maryam Qachouh, Mohamed Rachid, Abdellah Madani, Nisrine Khoubila
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引用次数: 0

摘要

我们对83例20岁以下的免疫性血小板减少症(IT)患者进行了回顾性研究。目的是为我们的年轻患者提供信息技术的概述。中位年龄为10岁,以女性为主(71%)。最常见的就诊原因是54%的病例中皮肤(65%)或粘膜皮肤(24%)中度出血综合征(布坎南3级)。77%的患者出现初始血小板减少≤20000/mm³,中位数为8000/mm³。51例患者要求进行骨髓显影。皮质类固醇仍然是最常用的处方药(87%),5例患者立即使用静脉注射免疫球蛋白。在一线治疗失败后,18例(22%)患者使用了利妥昔单抗和伊曲巴。11例患者行脾切除术,有效率82%。31%的患者出现慢性疾病进展。总体预后良好,男性和布坎南出血3级提示预后较好。
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[Immune thrombocytopenia in people under the age of twenty : a ten-year experience of a pediatric hematology and oncology department in Casablanca].

We conducted a retrospective study of 83 cases of immune thrombocytopenia (IT) in patients under 20 years of age. The aim was to provide an overview of IT in our young patients. The median age was 10 years, with a predominance of females (71 %). The most common reason for consultation was cutaneous (65 %) or mucocutaneous (24 %) haemorrhagic syndrome of moderate severity (Buchanan grade 3) in 54 % of cases. Initial thrombocytopenia ≤ 20000/mm³ was noted in 77 % of cases, with a median of 8000/mm³. Myelograms were requested in 51 patients. Corticosteroids continued to be the most commonly prescribed drug (87 %), with intravenous immunoglobulins used immediately in 5 patients. Rituximab and eltrombopag were used in 18 patients (22 %) after failure of first-line treatment. Splenectomy was performed in 11 patients, with a good response rate of 82 %. Chronic disease progression was seen in 31 % of patients. The overall prognosis was good, with male gender and Buchanan haemorrhagic grade 3 suggesting a more favourable outcome.

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